Document Detail

Prognostic factors in meningococcal disease. Development of a bedside predictive model and scoring system. Barcelona Meningococcal Disease Surveillance Group.
MedLine Citation:
PMID:  9256224     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Meningococcal disease is associated with significant morbidity and mortality. Development of a prognostic model based on clinical findings may be useful for identification and management of patients with meningococcal infection.
OBJECTIVES: To construct and validate a bedside model and scoring system for prognosis in meningococcal disease.
DESIGN: Prospective, population-based study.
SETTING: Twenty-four hospitals in the metropolitan area of Barcelona, Spain.
PATIENTS: A total of 907 patients with microbiologically proven meningococcal disease. Patients diagnosed with meningococcal disease from 1987 through 1990 were used to develop the prognostic model, and those diagnosed in 1991 and 1992 were used to validate it.
OUTCOME MEASURES: Clinical independent prognostic factors for mortality in meningococcal disease. The association between outcome and independent prognostic factors was determined by logistic regression analysis. A scoring system was constructed and tested using receiver operating characteristic curves.
RESULTS: Among 624 patients in the derivation set, 287 (46%) were male, the mean age was 12.4 years, and 34 patients (5.4%) died. Among 283 patients in the validation set, 124 (43.8%) were male, the mean age was 12.7 years, and 17 patients (6.0%) died. In multivariate analysis, independent predictors of death were hemorrhagic diathesis (odds ratio [OR], 101; 95% confidence interval [CI], 30-333), focal neurologic signs (OR, 25; 95% CI, 7-83), and age 60 years or older (OR, 10; 95% CI, 3-34), whereas receipt of adequate antibiotic therapy prior to admission was associated with reduced likelihood of death (OR, 0.09; 95% CI, 0.02-0.4). Hemorrhagic diathesis was scored with 2 points, presence of focal neurologic signs with 1 point, age of 60 years or older with 1 point, and preadmission antibiotic therapy was scored as -1. The clinical scores of -1, 0, 1, 2, and 3 or more points were associated with a probability of death of 0%, 2.3%, 27.3%, 73.3%, and 100%, respectively.
CONCLUSIONS: Hemorrhagic diathesis, focal neurologic signs, and age of 60 years or older were independent predictors of death in meningococcal disease, whereas receipt of adequate antibiotic therapy was associated with a more favorable prognosis. The scoring system presented is simple, is based on findings readily available at the bedside, and may be useful to help guide aggressive therapy.
N Barquet; P Domingo; J A Caylà; J González; C Rodrigo; P Fernández-Viladrich; F A Moraga-Llop; F Marco; J Vázquez; J A Sáez-Nieto; J Casal; J Canela; M Foz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA     Volume:  278     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-08-21     Completed Date:  1997-08-21     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-6     Citation Subset:  AIM; IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Central Nervous System Diseases / etiology
Child, Preschool
Hemorrhagic Disorders / etiology
Hospital Mortality*
Hospitals, Urban
Logistic Models
Meningococcal Infections / drug therapy,  mortality*,  physiopathology
Middle Aged
Models, Statistical
Multivariate Analysis
Outcome Assessment (Health Care)*
Prospective Studies
ROC Curve
Severity of Illness Index
Spain / epidemiology
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
JAMA. 1997 Nov 26;278(20):1658-9   [PMID:  9388080 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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