Document Detail

Prognostic factors in maxillary sinus and nasal cavity carcinoma.
MedLine Citation:
PMID:  15923101     Owner:  NLM     Status:  MEDLINE    
AIMS: The aim of the present study is to define prognostic factors, particularly the impact of treatment on paranasal sinus and nasal cavity malignancies. MATERIAL AND METHODS: Retrospective study of patients with maxillary antrum and nasal fossae malignancies. A maxillectomy classification as performed to treat malignancies in our institution is described. Multivariate analysis of prognostic factors was done using the Cox's model. RESULTS: One hundred and nine patients were evaluated. Squamous cell carcinoma was found in 62 cases and in 95 patients the epicentre of the tumour was located in the maxillary antrum. Ten patients were treated with surgery only, 39 patients with surgery and adjuvant radiation therapy, 37 cases received only radiotherapy, and 18 received radiotherapy followed by surgery; in five cases a combination of chemo-radiotherapy was used. Multivariate analysis identified T classification, orbit invasion, N classification, site of origin of tumour in nasal fossae, and no surgical resection as independent prognostic factors (p=0.0001). CONCLUSION: T4 tumours with orbit invasion present bad prognosis as compared to other T4 tumours. Surgical resection should be included in the treatment strategy. Because of the high frequency of lymph-node metastasis, neck treatment should be considered in T4 tumours.
J F Carrillo; A Güemes; M C Ramírez-Ortega; L F Oñate-Ocaña
Publication Detail:
Type:  Journal Article     Date:  2005-05-31
Journal Detail:
Title:  European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology     Volume:  31     ISSN:  0748-7983     ISO Abbreviation:  Eur J Surg Oncol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-29     Completed Date:  2006-01-31     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  8504356     Medline TA:  Eur J Surg Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1206-12     Citation Subset:  IM    
Head and Neck Department, Subdirección de Cirugía, Instituto Nacional de Cancerología, Mexico City, Mexico.
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MeSH Terms
Adenocarcinoma / mortality,  pathology,  therapy*
Aged, 80 and over
Carcinoma, Squamous Cell / mortality,  pathology,  therapy*
Combined Modality Therapy
Maxilla / surgery
Maxillary Sinus Neoplasms / mortality,  pathology,  therapy*
Middle Aged
Nasal Cavity
Neoplasm Staging
Nose Neoplasms / mortality,  pathology,  therapy*
Otorhinolaryngologic Surgical Procedures
Retrospective Studies
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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