| Prognostic factors in the management of metastatic epidural spinal cord compression. | |
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MedLine Citation:
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PMID: 6678303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The results of 51 patients with metastatic spinal cord compression were analyzed. There were seven paralyzed patients, three received radiotherapy (RT) alone and four received laminectomy (L) + RT. No patient regained any motor function. Of six ambulatory patients, half received RT and half L + RT. All remained ambulatory after the treatment. Of 38 paraparetic patients, 20 underwent L + RT. Their complete, partial and nonresponse (CR, PR, NR respectively) rates were 25%, 60% and 15%, respectively. This result was clearly better than 18 other patients treated by RT alone of which only 22% regained ambulation (CR = 22%) while 67% were NR and 11% had a PR. In this series combined modality therapy appears better in paraparetic patients. Five patients with radiosensitive tumors all had CR/PR whether treated by RT or L + RT. Patients with epithelial tumors treated by L + RT had a PR (CR + PR) of 71% while RT alone gave only 25%. On the basis of this analysis we conclude: (1) ambulatory patients respond satisfactorily to RT alone; (2) paraparetic patients with radiosensitive tumors do well with RT alone while such patients with epithelial tumors merit L + RT; but (3) paraplegic patients rarely benefit from either modality; (4) pain control appears a useful measure of minimally adequate radiation dose in individual patients. |
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Authors:
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S G Tang; J E Byfield; T R Sharp; J F Utley; L Quinol; S L Seagren |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuro-oncology Volume: 1 ISSN: 0167-594X ISO Abbreviation: J. Neurooncol. Publication Date: 1983 |
Date Detail:
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Created Date: 1984-09-19 Completed Date: 1984-09-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 21-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Combined Modality Therapy Epidural Space Female Humans Laminectomy Male Middle Aged Paralysis / etiology, therapy Prognosis Spinal Cord Compression / etiology, therapy* Spinal Neoplasms / complications, radiotherapy, secondary* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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