| Prognostic factors in lung cancer in a defined geographical area over two decades with a special emphasis on gender. | |
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MedLine Citation:
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PMID: 22380488 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Many studies over recent decades report an increasing incidence of lung cancer in female patients. Female gender is often reported as a good prognostic factor. Objectives: The aim of the present study was to investigate prognostic factors with a special emphasis on gender. Methods: During 1989-2008, 1497 patients in eastern Scania, a part of southern Sweden with 202 000 inhabitants, were referred to one Central Hospital and prospectively registered. All patients were grouped into four 5-year periods and analysed for occurrence of lung cancer, patient performance status, types and stages of lung cancer and the relation to gender. Results: The incidence of lung cancer more than doubled in women. The proportion of adenocarcinomas increased in females and males to 57 % (p=0.028) and 42 % (p=0.001), respectively, while the frequency of small cell lung carcinomas (SCLCs) decreased in both genders to approximately 14 %. Females had significantly more frequent stage 1 (16.6 %) and higher surgery rate (23.1 %) than males (12 % and 18.2 %, respectively). Females showed a higher 5-year survival rate than males (20.1 % and 11.5 %, respectively; p<0.001). Patients with non-small cell lung carcinoma (NSCLC) had a higher 5-year survival rate than those with SCLC (16.5 % and 7.5 %, respectively; p<0.01); however there was no significant survival difference in females between NSCLC and SCLC. Conclusion: Female patients exhibited longer survival than males for both NSCLC and SCLC, and this was not explained by a higher frequency of stage 1 or surgery in NSCLC. © 2012 Blackwell Publishing Ltd. |
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Authors:
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Gunnar Svensson; Sven-Börje Ewers; Ola Ohlsson; Håkan Olsson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-1 |
Journal Detail:
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Title: The clinical respiratory journal Volume: - ISSN: 1752-699X ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101315570 Medline TA: Clin Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Department of Medicine, Central Hospital, Kristianstad, Sweden Department of Oncology, University Hospital, Lund, Sweden Department of Cancer Epidemiology, Clinical Sciences, University of Lund, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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