Document Detail

Prognostic factors in lactic acidosis syndrome caused by nucleoside reverse transcriptase inhibitors: report of eight cases and review of the literature.
MedLine Citation:
PMID:  15307926     Owner:  NLM     Status:  MEDLINE    
We conducted a retrospective study to identify prognostic factors in the lactic acidosis syndrome (LAS) caused by nucleoside reverse transcriptase inhibitors (NRTIs) in patients with HIV/AIDS. Fifty-eight cases of LAS were included in our analysis, 8 from our hospital spanning the years 1992-2002, and 50 reported in the English language literature from 1986 through 2002. Peak venous lactate level was the best predictor of mortality. Zidovudine was associated with higher lactate levels and higher mortality than stavudine and lamuvidine. Mortality declined progressively after 1986 when the first cases of NRTI-related LAS were described. Increased mortality with zidovudine in this study appears due in part to its greater use prior to 1990 when LAS was not widely recognized as a potential complication of NRTI therapy.
Naga S Tripuraneni; Peter R Smith; Jeremy Weedon; Ute Rosa; Douglas Sepkowitz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  AIDS patient care and STDs     Volume:  18     ISSN:  1087-2914     ISO Abbreviation:  AIDS Patient Care STDS     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-13     Completed Date:  2004-09-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9607225     Medline TA:  AIDS Patient Care STDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  X    
Division of Pulmonary Medicine Long Island College Hospital, Brooklyn, New York 11201, USA.
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MeSH Terms
Acidosis, Lactic / chemically induced*,  epidemiology*,  mortality
Didanosine / adverse effects
HIV Infections / drug therapy*
Lamivudine / adverse effects
Middle Aged
New York / epidemiology
Reverse Transcriptase Inhibitors / adverse effects*
Stavudine / adverse effects
Zidovudine / adverse effects
Reg. No./Substance:
0/Reverse Transcriptase Inhibitors; 134678-17-4/Lamivudine; 30516-87-1/Zidovudine; 3056-17-5/Stavudine; 69655-05-6/Didanosine

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