| Prognostic factors depicting disease-specific survival in parotid-gland tumors. | |
| | |
MedLine Citation:
|
PMID: 17398019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To identify significant prognostic factors that can be used in clinical decision-making with regard to parotid cancer, which is characterized by a complex and diverse group of tumors with variable outcomes. METHODS AND MATERIALS: A historical cohort of 184 patients with parotid-gland malignancy, who had been registered in the Province of Manitoba from 1970 to 2003, was examined. Survival analysis was performed using Kaplan-Meier curves and a log-rank test for comparing subgroups. The independent effect of factors that predicted survival at the bivariate level was determined using a Cox proportional hazard model. RESULTS: The mean age at presentation was 62 years. The mean follow-up was 64 months. Absolute and disease-specific survival at 5 years was 41.70% and 57.94%, respectively. Survival for Stages I-IV at 5 years was 85.35%, 76.9%, 56.1%, and 8.4%, respectively (p < 0.0001). Factors with an independent effect on survival (p < 0.05) included age, tumor size, local invasion (Stages T4 vs. T1), and distant metastasis at presentation, tumor differentiation, and treatment. Adjuvant radiotherapy vs. surgery alone reduced the risk of death from disease at 5 years by 50% (hazard ratio [HR], 0.5; 95% confidence interval, 0.228-0.995; p = 0.0486). CONCLUSIONS: Despite the variety of malignant parotid tumors, easily identifiable prognostic indicators such as advanced age, tumor size, local invasion, and tumor differentiation have a significant impact on outcome. Patients with adverse prognostic factors benefit from adjuvant radiotherapy. The threshold for the use of adjuvant radiotherapy in managing parotid malignancy should be low. |
| | |
Authors:
|
Rashmi Koul; Arbind Dubey; James Butler; Andrew L Cooke; Ahmed Abdoh; Richard Nason |
Related Documents
:
|
20678359 - Making evidence available: prognostic classification systems. 9443459 - Prognostic indicators of survival in als. als cntf treatment study group. 19850329 - Evaluating the prognostic factors effective on the outcome of patients with glioblastom... 22963569 - Progress and pitfalls in the identification of cancer stem cell-targeting therapies in ... 11719359 - Identification of poor prognostic features among patients requiring mechanical ventilat... 17885489 - Prognostic value of measurements of angiogenesis in serous carcinoma of the ovary. 22809039 - Outcomes and prognostic factors in patients with a single lymph node metastasis at time... 8152279 - Therapeutic progress and comparative aspects in chronic myelogenous leukemia (cml): int... 17660069 - Outcomes after resection of synchronous or metachronous hepatic and pulmonary colorecta... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-29 |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: 68 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2007 Jul |
Date Detail:
|
Created Date: 2007-06-04 Completed Date: 2007-08-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
|
Languages: eng Pagination: 714-8 Citation Subset: IM |
Affiliation:
|
Department of Radiation Oncology, CancerCare Manitoba, Winnipeg, Manitoba, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Female Humans Incidence Male Manitoba / epidemiology Middle Aged Oral Surgical Procedures / mortality* Outcome Assessment (Health Care) / methods* Parotid Neoplasms / mortality*, surgery, therapy* Prognosis Radiotherapy, Adjuvant / mortality* Risk Assessment / methods* Risk Factors Survival Analysis Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: PET-CT-based auto-contouring in non-small-cell lung cancer correlates with pathology and reduces int...
Next Document: Fatigue during head-and-neck radiotherapy: prospective study on 117 consecutive patients.