| Prognostic effect of renal dysfunction after ST-segment elevation myocardial infarction with and without heart failure. | |
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MedLine Citation:
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PMID: 16290104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The present study was designed to assess, 1) the independent prognostic effect of renal dysfunction on all-cause mortality in the setting of acute myocardial infarction with ST-segment elevation (STEMI), and 2) to determine if such effect varies based upon the presence of heart failure (HF) on admission. METHODS: 549 consecutive patients admitted with the diagnosis of STEMI were prospectively recruited in a teaching hospital in Spain. Serum creatinine (sCr) and glomerular filtration rate (GFR) were obtained on admission, together with other relevant information used for risk stratification. The independent effect of sCr and GFR on long-term mortality was determined by Cox regression analysis. Main outcome was all-cause mortality, with a median follow-up of 1 year. RESULTS: In a multivariate analysis the degree of renal impairment was a strong predictor of mortality in patients without clinical evidence of HF at admission (HR=1.15; 95% CI 1.10 to 1.19 and HR=1.58; 95% CI 1.30 to 1.81) for sCr (per 0.1 mg/dl) and GFR (per decreasing 10 ml/min/1.73 m2), respectively. In the group with HF, the effect was less pronounced (HR=1.03; 95% CI 1.01 to 1.04 and HR=1.17; 95% CI 1.02 to 1.37) for sCr and GFR, respectively. CONCLUSIONS: In the setting of STEMI, renal dysfunction estimates showed a differential prognostic effect depending on HF status, with a greater impact seen in patients without clinical evidence of HF. |
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Authors:
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Vicente Bertomeu-Gonzalez; Julio Núñez; Eduardo Núñez; Lorenzo Fácila; Juan Sanchis; Vicent Bodí; Mauricio Pellicer; María J Bosch; Angel Martínez; Francisco J Chorro; Angel Llàcer |
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Publication Detail:
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Type: Journal Article Date: 2005-11-10 |
Journal Detail:
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Title: International journal of cardiology Volume: 112 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-18 Completed Date: 2006-10-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Affiliation:
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Cardiology Department, Valencia Clinic University Hospital, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain. vbertog@secardiologia.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Comorbidity Creatinine / blood Female Glomerular Filtration Rate Heart Failure / epidemiology*, physiopathology Humans Kidney / physiopathology* Male Middle Aged Multivariate Analysis Myocardial Infarction / epidemiology, mortality*, physiopathology* Prognosis Prospective Studies Risk Assessment Stroke Volume Survival Analysis |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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