Document Detail

Prognostic determinants after hepatoportoenterostomy for biliary atresia.
MedLine Citation:
PMID:  7457728     Owner:  NLM     Status:  MEDLINE    
Hepatic secretory functions were measured postoperatively in 17 infants undergoing hepatoportoenterostomy for biliary atresia. These studies were compared in surviving and nonsurviving infants to attempt early identification of infants who might require reoperation. Statistically significant differences between surviving and nonsurviving infants were found in alkaline phosphatase clearances at 1, 4, 12 and 24 weeks postoperatively. In addition, bilirubin clearance and secreted 24 hour bilirubin measurements were significantly increased in survivors 12 and 24 weeks postoperatively. Iodine-131 rose bengal excretion, measured 6 months postoperatively, was likewise significantly increased in survivors. Six of the 10 surviving infants required reoperation when their secretory functions deteriorated; all improved postoperatively. None of the seven nonsurviving infants underwent reoperation. Biliary secretory functions have early prognostic significance and apparently can predict which infants require reoperation. Reexploration and higher transection of atretic ducts may improve survival.
T R Weber; J L Grosfeld; J F Fitzgerald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  141     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  AIM; IM    
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MeSH Terms
Alkaline Phosphatase / metabolism
Bile Ducts / abnormalities*,  surgery
Bilirubin / metabolism
Intestines / surgery*
Iodine Radioisotopes
Liver / secretion,  surgery*
Prospective Studies
Rose Bengal / metabolism
Reg. No./Substance:
0/Iodine Radioisotopes; 11121-48-5/Rose Bengal; 635-65-4/Bilirubin; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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