Document Detail

Prognostic classification of Hodgkin disease in pathologic stage III, based on anatomic considerations.
MedLine Citation:
PMID:  861375     Owner:  NLM     Status:  MEDLINE    
Fifty-two patients with pathologic stage III Hodgkin disease were studied in an effort to determine whether location of involved abdominal nodes influenced survival. Treatment consisted of total nodal radiotherapy with or without subsequent combination chemotherapy. Th initial radiation field was the "extended mantle," which included supradiaphragmatic nodes, the splenic hilar area, and paraaortic nodes to the level of L2-L4. Subsequently, lower paraaortic and iliac regions were treated ("lower inverted Y"). Patients with disease limited to the spleen and/or splenic, celiac, or portal nodes ("anatomic substage" III1) had a more favorable 5-yr survival than did patients with involvement of paraaortic, iliac, or mesenteric nodes ("anatomic substage" III2): 93% versus 57%, respectively (p less than 0.05). The addition of combination chemotherapy to total nodal irradiation was associated with improved survival of patients in stage III2, but not of those in stage III1.
R K Desser; H M Golomb; J E Ultmann; D J Ferguson; E M Moran; M L Griem; J Vardiman; B Miller; N Oetzel; D Sweet; E P Lester; J J Kinzie; R Blough
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  49     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  883-93     Citation Subset:  AIM; IM    
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MeSH Terms
Hodgkin Disease / mortality,  pathology*,  radiotherapy
Lymph Nodes / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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