Document Detail

Prognostic assessment of end-stage cardiac failure.
MedLine Citation:
PMID:  9684036     Owner:  NLM     Status:  MEDLINE    
Heart failure is not a disease, but rather a complex clinical syndrome that is growing in incidence and carries a very high morbidity and mortality. Although the incidence in the general adult population in the Western world is between 1% and 2%, the frequency increases rapidly in the elderly affecting more than 10% of the individuals over the age of 75 years. The treatment of patients with end-stage chronic heart failure (CHF) is difficult. The two major goals in the treatment of heart failure are to increase the duration (slow its progression) and quality of life (relief of symptoms). Understanding the severity of the syndrome of heart failure in terms of its prognosis can be particularly important in planning long-term management and in counselling the patient. The introduction of aggressive interventional therapies such as active haemodynamic support with ventricular assist devices, or heart transplantation emphasizes the importance of quantitating the risk of death in order to properly select patients for these more aggressive treatments. In large-scale trials it has been possible to identify markers that serve as significant predictors of mortality. Of these, the detection and quantification of neurohumoral activation have gained the most recent attention. Here, we discuss some of the prognostic tools in current use for heart failure patients and their applicability to patients with advanced heart failure.
P Vranckx; J Van Cleemput
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta cardiologica     Volume:  53     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  1998  
Date Detail:
Created Date:  1998-10-28     Completed Date:  1998-10-28     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  IM    
Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Belgium.
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MeSH Terms
Heart Failure / diagnosis*,  mortality,  therapy
Heart-Assist Devices
Quality of Life
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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