Document Detail


Prognostic value of serum neutrophil gelatinase-associated lipocalin in metastatic and nonmetastatic colorectal cancer.
MedLine Citation:
PMID:  23389669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) expression is increased in epithelial cancer patients, but studies showing its relation to prognosis are scarce. We aimed to test the ability of preoperative serum NGAL levels (pNGAL) to predict recurrence in metastatic and nonmetastatic colorectal cancer (CRC) patients.
METHODS: This retrospective study determined pNGAL levels in 60 healthy individuals, 47 patients with nonmetastatic CRC, and 70 patients with metastatic CRC undergoing curative neoplastic resection. Patients were divided into low- and high-pNGAL groups using a median series-based cutoff.
RESULTS: The mean ± SD pNGAL in CRC patients (nonmetastatic and metastatic) was 102.3 ± 66.6 (median 91.4). Nonmetastatic CRC and metastatic CRC patients had higher pNGAL than healthy controls (88 ± 64 and 112 ± 67 vs. 0.6 ± 0.3, respectively, both p < 0.0001). Nonmetastatic CRC patients with deeper tumor invasion and metastatic CRC patients with shorter disease-free interval after CRC resection had higher pNGAL. pNGAL levels correlated with neoplastic tissue volume. CRC patients with recurrence had higher pNGAL than those without recurrence (118 ± 64 vs. 88 ± 66, p = 0.013), and high-pNGAL patients had a higher recurrence rate (59.3 vs. 36.2 %, p = 0.016). Median pNGAL-based risk classification had a sensitivity of 62.5 % for predicting neoplastic progression in CRC patients and 74.3 % for predicting neoplastic progression during the first year after metastatic CRC resection.
CONCLUSIONS: pNGAL is higher in CRC patients than in the healthy population, which indicates a potential screening role. High-pNGAL levels are associated with higher neoplastic tissue volume, characteristics of neoplastic invasion, and recurrence, showing a prognostic utility mainly in metastatic CRC patients.
Authors:
Josep Martí; Josep Fuster; Anna M Solà; Georgina Hotter; Rafael Molina; Amalia Pelegrina; Joana Ferrer; Ramon Deulofeu; Constantino Fondevila; Juan Carlos García-Valdecasas
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  37     ISSN:  1432-2323     ISO Abbreviation:  World J Surg     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-08     Completed Date:  2013-10-17     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1103-9     Citation Subset:  IM    
Affiliation:
Liver Surgery and Transplantation Unit, Institut Clínic de Malalties Digestives i Metabolisme, IDIBAPS, Hospital Clínic i Provincial, CIBERehd, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins
Adult
Aged
Aged, 80 and over
Case-Control Studies
Colorectal Neoplasms / blood*,  mortality,  pathology,  surgery
Female
Follow-Up Studies
Humans
Lipocalins / blood*
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Recurrence, Local / blood
Preoperative Period
Proto-Oncogene Proteins / blood*
Retrospective Studies
Survival Analysis
Treatment Outcome
Tumor Burden
Tumor Markers, Biological / blood*
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 0/Tumor Markers, Biological
Comments/Corrections
Comment In:
World J Surg. 2013 Nov;37(11):2729   [PMID:  23887597 ]
World J Surg. 2013 Nov;37(11):2727-8   [PMID:  23778838 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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