Document Detail


Prognostic Value of Renal Dysfunction for the Prediction of Outcome Versus Results of Computed Tomographic Coronary Angiography.
MedLine Citation:
PMID:  21784394     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chronic kidney disease (CKD) is associated with cardiovascular (CV) events caused by advanced atherosclerosis. Computed tomographic coronary angiography (CTA) can accurately diagnose coronary artery disease (CAD) and predict CV outcomes. The aim of the present study was to evaluate whether moderate CKD provides prognostic information for CV events in patients undergoing CTA. In total 885 patients with suspected CAD underwent CTA and were stratified to moderate CKD (85 patients) or no CKD (770 patients) based on a cut-off estimated glomerular filtration rate of 60 ml/min/1.73 m(2). After 896 days of follow-up, 42 patients developed CV events. Annualized CV event rates were 1.2% in patients with no CKD and no CAD, 2.5% in patients with moderate CKD alone, 2.5% in patients with obstructive CAD alone, and 3.7% in those with moderate CKD and obstructive CAD. Multivariate models demonstrated that moderate CKD (hazard ratio 2.39, confidence interval 1.09 to 5.21, p = 0.03) and obstructive CAD (hazard ratio 2.76, confidence interval 1.40 to 5.44, p <0.01) were independent predictors of CV events. Importantly, moderate CKD provided incremental prognostic information in addition to clinical characteristics and obstructive CAD (chi-square 49.4, p = 0.04). In conclusion, moderate CKD was associated with CV events and provided incremental prognostic information.
Authors:
Kai Hang Yiu; Fleur R de Graaf; Joanne D Schuijf; Jacob M van Werkhoven; Joella E van Velzen; Mark J Boogers; Cornelis J Roos; Mihály K de Bie; Aju Pazhenkottil; Lucia J Kroft; Eric Boersma; Bernhard Herzog; Albert de Roos; Philipp A Kaufmann; Jeroen J Bax; J Wouter Jukema
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-22
Journal Detail:
Title:  The American journal of cardiology     Volume:  -     ISSN:  1879-1913     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong, China.
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