Document Detail


The prognostic value of the neutrophil-lymphocyte ratio (NLR) in acute pancreatitis: identification of an optimal NLR.
MedLine Citation:
PMID:  23371356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The neutrophil-lymphocyte ratio (NLR), calculated from the white cell differential count, provides a rapid indication of the extent of an inflammatory process. The aim of this study was to investigate the prognostic value of the NLR in acute pancreatitis (AP) and determine an optimal ratio for severity prediction.
MATERIALS AND METHODS: NLRs were calculated on days 0, 1, and 2, and correlated with severity. Severity was defined using the Atlanta classification.
RESULTS: One hundred forty-six consecutive patients managed were included, 22 with severe acute pancreatitis (SAP). NLR in SAP was significantly higher than in the favorable prognosis group on all 3 days (day 0, 15.5 vs. 10.5; day 1, 13.3 vs. 9.8; day 2, 10.8 vs. 7.6). The optimal cut-offs from ROC curves were 10.6 (day 0), 8.1 (day 1), and 4.8 (day 2) giving sensitivities of 63-90 %, specificities of 50-57 %, negative predictive value of 89.5-96.4 %, positive predictive values of 21.2-31.1 %, and accuracies of 57.7-60 %.
CONCLUSIONS: Elevation of the NLR during the first 48 h of admission is significantly associated with severe acute pancreatitis and is an independent negative prognostic indicator in AP.
Authors:
Aravind Suppiah; Deep Malde; Tameem Arab; Mazin Hamed; Victoria Allgar; Andrew M Smith; Gareth Morris-Stiff
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Publication Detail:
Type:  Journal Article     Date:  2013-02-01
Journal Detail:
Title:  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract     Volume:  17     ISSN:  1873-4626     ISO Abbreviation:  J. Gastrointest. Surg.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-23     Revised Date:  2014-04-28    
Medline Journal Info:
Nlm Unique ID:  9706084     Medline TA:  J Gastrointest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  675-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Female
Humans
Leukocyte Count
Lymphocytes*
Male
Middle Aged
Neutrophils*
Pancreatitis / blood*
Prognosis
Severity of Illness Index
Time Factors
Comments/Corrections
Comment In:
J Gastrointest Surg. 2014 Apr;18(4):885   [PMID:  24395068 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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