Document Detail

Prognostic Value of Capnography During Rest and Exercise in Patients With Heart Failure.
MedLine Citation:
PMID:  22537025     Owner:  NLM     Status:  Publisher    
New variables obtained from cardiopulmonary exercise testing (CPX) have received attention in recent years, in particular the partial pressure of end-tidal carbon dioxide (P(ET) CO(2) ). The purpose of this study was to therefore comprehensively assess the ability of resting and exercise P(ET) CO(2) to predict major cardiac events in a heart failure (HF) cohort referred for CPX. A total of 963 patients with systolic HF undergoing symptom-limited CPX were included in the analysis. Resting and exercise P(ET) CO(2) along with other CPX variables were determined, and patients were followed for major adverse events. With regard to resting measures, multivariate analysis revealed that left ventricular ejection fraction was the most robust prognostic marker (P<.001) while resting P(ET) CO(2) added significant predictive value and was retained in the regression (P<.001). When exercise data were considered, the multivariate analysis revealed that the P(ET) CO(2) apex during exercise added predictive value and was retained (P<.05). In what is the largest evaluation of P(ET) CO(2) in the assessment of systolic HF patients to date, the authors substantiate prior (smaller) studies showing prognostic utility of P(ET) CO(2) , both as a resting measure (an important potential screening tool) and during exercise. These data add to the rationale to incorporate P(ET) CO(2) as a routine monitoring component in HF management. 00:00-00. ©2012 Wiley Periodicals, Inc.
Ross Arena; Marco Guazzi; Jonathan Myers; Paul Chase; Daniel Bensimhon; Lawrence P Cahalin; Mary Ann Peberdy; Euan Ashley; Erin West; Daniel E Forman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-26
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  -     ISSN:  1751-7133     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
From the Physical Therapy Program, Department of Orthopaedics and Rehabilitation, School of Medicine, University of New Mexico, Albuquerque, NM;Division of Cardiology, Department of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM;Cardiology, I.R.C.C.S. Policlinico San Donato, University of Milano, San Donato Milanese, Italy; Division of Cardiology, VA Palo Alto Healthcare System, Palo Alto, CA;Lebauer Cardiovascular Research Foundation, Greensboro, NC;Department of Physical Therapy, Leonard M. Miller School of Medicine, University of Miami, Miami, FL;Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA;Cardiovascular Medicine, Stanford University, Palo Alto, CA;Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA.
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