Document Detail

Prognostic significance of a systemic inflammatory response in patients undergoing multimodality therapy for advanced colorectal cancer.
MedLine Citation:
PMID:  23147449     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The inflammation-based Glasgow Prognostic Score (GPS) is associated with outcome in a variety of cancers. This study investigated whether a modified GPS (mGPS) could predict survival in patients undergoing multimodality therapy for advanced colorectal cancer (CRC).
METHODS: We enrolled 245 patients with advanced CRC who received chemotherapy. The mGPS was recorded prior to first-line chemotherapy and to cytoreductive therapy including secondary surgery and/or radiofrequency ablation. The prognostic significance of the mGPS was analyzed using Kaplan-Meier, univariate, and multivariate analyses.
RESULTS: In patients who received chemotherapy alone (n = 163), the mGPS prior to chemotherapy was an independent prognostic indicator of survival [odds ratio (OR) 1.858; 95% confidence interval (CI) 1.213-2.846; p = 0.0044]. In patients who also underwent cytoreductive therapy (n = 82), the mGPS decreased after chemotherapy in 22 patients (27%) and increased in 5 (6%). In these patients, the mGPS prior to cytoreductive therapy was an independent prognostic indicator of survival (OR 3.412; 95% CI 1.198-9.720; p = 0.0216), but the mGPS prior to chemotherapy was not.
CONCLUSIONS: The mGPS is an independent prognostic indicator of survival in patients undergoing multimodality therapy for advanced CRC, if recorded at a relevant time point.
Yasuhiro Inoue; Takashi Iwata; Yoshinaga Okugawa; Aya Kawamoto; Junichiro Hiro; Yuji Toiyama; Koji Tanaka; Keiichi Uchida; Yasuhiko Mohri; Chikao Miki; Masato Kusunoki
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Publication Detail:
Type:  Journal Article     Date:  2012-11-09
Journal Detail:
Title:  Oncology     Volume:  84     ISSN:  1423-0232     ISO Abbreviation:  Oncology     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-21     Completed Date:  2013-02-21     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  100-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Adenocarcinoma / mortality*,  pathology,  therapy
Aged, 80 and over
C-Reactive Protein / metabolism
CA-19-9 Antigen / metabolism
Carcinoembryonic Antigen / metabolism
Colorectal Neoplasms / complications,  mortality*,  therapy
Combined Modality Therapy / adverse effects*
Follow-Up Studies
Inflammation / diagnosis,  etiology*,  metabolism
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Retrospective Studies
Serum Albumin / metabolism
Survival Rate
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/CA-19-9 Antigen; 0/Carcinoembryonic Antigen; 0/Serum Albumin; 0/Tumor Markers, Biological; 9007-41-4/C-Reactive Protein
Comment In:
Oncology. 2014;86(1):44-5   [PMID:  24356426 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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