| Prognostic significance of interictal epileptiform discharges after epilepsy surgery. | |
| | |
MedLine Citation:
|
PMID: 20634715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The prognostic significance of interictal epileptiform discharges (IED) after epilepsy surgery is uncertain. We reviewed 20 studies (including 2 unpublished data sets) to assess the usefulness of postoperative EEG findings in predicting seizure outcome after resective epilepsy surgery. Patient selection and methodology varied widely among the studies. The published studies included 1,345 patients (temporal resection, n = 751; extratemporal resection, n = 373; unspecified site, n = 221). We defined a favorable outcome as a postoperative seizure status of Engel class I or equivalent. The frequency of postoperative IED ranged from 13% to 68% (mean, 31.5%). Postoperative IED were strongly associated with an unfavorable seizure outcome for the whole cohort (odds ratio, 3.3; 95% confidence interval, 2.5-4.5), for the subgroup of patients who underwent temporal resection (odds ratio, 2.5; 95% confidence interval, 1.6-4.0), and for the extratemporal resection subgroup (odds ratio, 5.6; 95% confidence interval, 3.9-9.3). Postoperative IED had a modest positive predictive value (52%) but an excellent negative predictive value (71%) for unfavorable seizure outcome. Most IED (>90%) were localized to the site of resection and were also influenced by preoperative spike frequency and completeness of resection. Insufficient data preclude any firm conclusions about the value of postoperative IED in predicting seizure outcomes after hemispherotomy or corpus callosotomy. |
| | |
Authors:
|
Chaturbhuj Rathore; Kurupath Radhakrishnan |
Related Documents
:
|
10690715 - Microsurgical resection of brainstem, thalamic, and basal ganglia angiographically occu... 18807365 - Diagnoses in epilepsy commonly treated with surgery. 17317995 - Epilepsy. 8319235 - Surgical indication in children with congenital hemiparesis. 10894905 - Preoperative predictors of late postoperative outcome among patients with nonischemic m... 17598675 - Decontamination and traceability of flexible endoscopes. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society Volume: 27 ISSN: 1537-1603 ISO Abbreviation: J Clin Neurophysiol Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-04 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8506708 Medline TA: J Clin Neurophysiol Country: United States |
Other Details:
|
Languages: eng Pagination: 255-62 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Brain / physiopathology, surgery* Brain Waves* Child Corpus Callosum / surgery Electroencephalography Epilepsy / diagnosis*, physiopathology, surgery* Hemispherectomy Humans Neurosurgical Procedures* / adverse effects Odds Ratio Predictive Value of Tests Prognosis Recurrence Risk Assessment Risk Factors Time Factors Treatment Outcome Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Symposium on the prognostic significance of interictal epileptiform discharges.
Next Document: Interictal epileptiform discharges in persons without a history of seizures: what do they mean?