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Prognostic Factors of Mortality in Very Low-Birth-Weight Infants with Neonatal Sepsis of Nosocomial Origin.
MedLine Citation:
PMID:  22893550     Owner:  NLM     Status:  Publisher    
Objective To identify the variables associated with sepsis-associated mortality, as well as to develop a severity risk score to predict death in very low-birth-weight (VLBW) neonates affected by nosocomial sepsis.Study Design Retrospective cohort study. Infants weighing ≤1500 g with neonatal sepsis of nosocomial origin were included. Epidemiological, clinical, and laboratory variables were recorded at onset (0 hours), at 12 hours, and at 24 hours. Bivariate and multivariate analyses were performed.Result The study population included 95 VLBW infants who presented 129 episodes of nosocomial sepsis. In the bivariate analysis, gram-negative bacilli as the etiology of sepsis, seizures, age, postconceptional age, weight, serum procalcitonin (24 hours), platelet count (24 hours), blood urea nitrogen (0 and 24 hours), creatinine (24 hours), diuresis (12 and 24 hours), mean blood pressure (12 and 24 hours), pH, base excess (0, 12, and 24 hours), and SpO2 (pulse oximetric saturation):Fio2 (fraction of inspired oxygen) ratio (12 and 24 hours) were significantly associated with mortality. In the multivariate analysis, weight at the onset of sepsis, base excess (0 hours), and SpO2:Fio2 ratio (12 hours) were independent predictors of mortality.Conclusion A lower weight at the onset of sepsis, base excess, and SpO2:Fio2 ratio are useful to predict nosocomial sepsis-associated mortality in VLBW infants.
Carlos Lobete Prieto; Belén Fernández Colomer; José Blas López Sastre
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-14
Journal Detail:
Title:  American journal of perinatology     Volume:  -     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Service of Neonatology, Hospital Universitario Central de Asturias, Asturias, Spain.
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