Document Detail


Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studies.
MedLine Citation:
PMID:  22912340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Injury to the anterior cruciate ligament (ACL) threatens an active lifestyle and exposes the patient to risk of early osteoarthritis (OA). ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. Primary ACL reconstruction (ACLR) has in general been effective at restoring functional stability, but patients' modifiable predictors of both short- and long-term validated outcomes and OA are largely unknown. The Multicenter Orthopaedic Outcomes Network (MOON) consortium was established in 2002 to enroll and longitudinally follow a population cohort of ACL reconstructed patients. The objective was to establish patient-specific predictive models of clinically important outcomes. Over the past 10 years, the overarching aims of this NIAMS-funded prospective multicenter cohort of ACL reconstructions has been threefold: (1) to identify both short- and long-term prognosis and predictors of sports function, activity level, and general health through validated patient-reported outcomes, (2) to identify the symptoms and signs of OA, and (3) to quantify the incidence of ACL reconstruction graft and/or contralateral ACL failures and additional surgical procedures. This manuscript summarizes the Kappa Delta Ann Doner Vaughan Award paper and presentation at the 2012 ORS/AAOS Annual Meeting.
Authors:
Kurt P Spindler; Richard D Parker; Jack T Andrish; Christopher C Kaeding; Rick W Wright; Robert G Marx; Eric C McCarty; Annunziato Amendola; Warren R Dunn; Laura J Huston; Frank E Harrell;
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2012-08-21
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  31     ISSN:  1554-527X     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2013-01-29     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Orthopaedic Research Society.
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MeSH Terms
Descriptor/Qualifier:
Anterior Cruciate Ligament / injuries*,  surgery*
Anterior Cruciate Ligament Reconstruction / standards*
Cohort Studies
Evidence-Based Medicine
Humans
Knee Injuries / epidemiology*,  surgery*
Models, Statistical
Multivariate Analysis
Osteoarthritis, Knee / epidemiology*
Predictive Value of Tests
Prognosis
Risk Factors
Grant Support
ID/Acronym/Agency:
5 U18-HS016075/HS/AHRQ HHS; 5K23 AR052392-05/AR/NIAMS NIH HHS; 5R01 AR053684/AR/NIAMS NIH HHS; K23 AR052392/AR/NIAMS NIH HHS; R01 AR053684/AR/NIAMS NIH HHS
Investigator
Investigator/Affiliation:
Morgan Jones / ; David C Flanigan / ; Brian R Wolf / ; Matthew J Matava / ; Robert H Brophy / ; Michelle Wolcott / ; Armando Vidal / ; Angela Pedroza / ; Leah Schmitz / ; Emily K Reinke /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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