| Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studies. | |
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MedLine Citation:
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PMID: 22912340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Injury to the anterior cruciate ligament (ACL) threatens an active lifestyle and exposes the patient to risk of early osteoarthritis (OA). ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. Primary ACL reconstruction (ACLR) has in general been effective at restoring functional stability, but patients' modifiable predictors of both short- and long-term validated outcomes and OA are largely unknown. The Multicenter Orthopaedic Outcomes Network (MOON) consortium was established in 2002 to enroll and longitudinally follow a population cohort of ACL reconstructed patients. The objective was to establish patient-specific predictive models of clinically important outcomes. Over the past 10 years, the overarching aims of this NIAMS-funded prospective multicenter cohort of ACL reconstructions has been threefold: (1) to identify both short- and long-term prognosis and predictors of sports function, activity level, and general health through validated patient-reported outcomes, (2) to identify the symptoms and signs of OA, and (3) to quantify the incidence of ACL reconstruction graft and/or contralateral ACL failures and additional surgical procedures. This manuscript summarizes the Kappa Delta Ann Doner Vaughan Award paper and presentation at the 2012 ORS/AAOS Annual Meeting. |
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Authors:
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Kurt P Spindler; Richard D Parker; Jack T Andrish; Christopher C Kaeding; Rick W Wright; Robert G Marx; Eric C McCarty; Annunziato Amendola; Warren R Dunn; Laura J Huston; Frank E Harrell; |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2012-08-21 |
Journal Detail:
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Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: 31 ISSN: 1554-527X ISO Abbreviation: J. Orthop. Res. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-11-26 Completed Date: 2013-01-29 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: United States |
Other Details:
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Languages: eng Pagination: 2-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Orthopaedic Research Society. |
Affiliation:
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Vanderbilt University Medical Center, 4200 Medical Center East, South Tower, 1215 21st Avenue South, Nashville, Tennessee 37232-8774, USA. kurt.spindler@vanderbilt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anterior Cruciate Ligament
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injuries*,
surgery* Anterior Cruciate Ligament Reconstruction / standards* Cohort Studies Evidence-Based Medicine Humans Knee Injuries / epidemiology*, surgery* Models, Statistical Multivariate Analysis Osteoarthritis, Knee / epidemiology* Predictive Value of Tests Prognosis Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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5 U18-HS016075/HS/AHRQ HHS; 5K23 AR052392-05/AR/NIAMS NIH HHS; 5R01 AR053684/AR/NIAMS NIH HHS; K23 AR052392/AR/NIAMS NIH HHS; R01 AR053684/AR/NIAMS NIH HHS |
| Investigator | |
Investigator/Affiliation:
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Morgan Jones / ; David C Flanigan / ; Brian R Wolf / ; Matthew J Matava / ; Robert H Brophy / ; Michelle Wolcott / ; Armando Vidal / ; Angela Pedroza / ; Leah Schmitz / ; Emily K Reinke / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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