Document Detail

Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studies.
MedLine Citation:
PMID:  22912340     Owner:  NLM     Status:  MEDLINE    
Injury to the anterior cruciate ligament (ACL) threatens an active lifestyle and exposes the patient to risk of early osteoarthritis (OA). ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. Primary ACL reconstruction (ACLR) has in general been effective at restoring functional stability, but patients' modifiable predictors of both short- and long-term validated outcomes and OA are largely unknown. The Multicenter Orthopaedic Outcomes Network (MOON) consortium was established in 2002 to enroll and longitudinally follow a population cohort of ACL reconstructed patients. The objective was to establish patient-specific predictive models of clinically important outcomes. Over the past 10 years, the overarching aims of this NIAMS-funded prospective multicenter cohort of ACL reconstructions has been threefold: (1) to identify both short- and long-term prognosis and predictors of sports function, activity level, and general health through validated patient-reported outcomes, (2) to identify the symptoms and signs of OA, and (3) to quantify the incidence of ACL reconstruction graft and/or contralateral ACL failures and additional surgical procedures. This manuscript summarizes the Kappa Delta Ann Doner Vaughan Award paper and presentation at the 2012 ORS/AAOS Annual Meeting.
Kurt P Spindler; Richard D Parker; Jack T Andrish; Christopher C Kaeding; Rick W Wright; Robert G Marx; Eric C McCarty; Annunziato Amendola; Warren R Dunn; Laura J Huston; Frank E Harrell;
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2012-08-21
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  31     ISSN:  1554-527X     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2013-01-29     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Orthopaedic Research Society.
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MeSH Terms
Anterior Cruciate Ligament / injuries*,  surgery*
Anterior Cruciate Ligament Reconstruction / standards*
Cohort Studies
Evidence-Based Medicine
Knee Injuries / epidemiology*,  surgery*
Models, Statistical
Multivariate Analysis
Osteoarthritis, Knee / epidemiology*
Predictive Value of Tests
Risk Factors
Grant Support
5 U18-HS016075/HS/AHRQ HHS; 5K23 AR052392-05/AR/NIAMS NIH HHS; 5R01 AR053684/AR/NIAMS NIH HHS; K23 AR052392/AR/NIAMS NIH HHS; R01 AR053684/AR/NIAMS NIH HHS
Morgan Jones / ; David C Flanigan / ; Brian R Wolf / ; Matthew J Matava / ; Robert H Brophy / ; Michelle Wolcott / ; Armando Vidal / ; Angela Pedroza / ; Leah Schmitz / ; Emily K Reinke /

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