| Prognosis of patients with left ventricular diastolic pressure abnormality: a long-term survival study in patients without coronary artery disease. | |
| | |
MedLine Citation:
|
PMID: 16596835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Given that an elevated left ventricular (LV) end-diastolic pressure reflects an abnormality of diastolic function, we analyzed the outcome of this finding in patients without coronary artery disease (CAD). HYPOTHESIS: The degree to which diastolic dysfunction influences mortality has been confounded in most studies by CAD and advanced age. METHODS: We performed a retrospective study of 876 patients with normal coronary arteries on arteriography. Of these, 115 patients had a left ventricular end-diastolic pressure of > or = 15 mmHg with an ejection fraction (EF) > or = 50%. We compared the mortality in this group (Group A) with the reported outcome in the general population, adjusted for age, gender, and race, as well as the mortality of a group of patients from the same cohort (Group B) with both diastolic and systolic dysfunction (n = 60), defined as a LVEF < 50%. RESULTS: Follow-up was for a mean of 63 months. In Group A, all-cause mortality was 5% (six patients); two deaths were from cardiac causes. The mean annual mortality in this group (1.2%) was similar to the adjusted annual mortality of the general population (1.1%), and it was significantly lower than the annual mortality (6%) in Group B (p < 0.03). CONCLUSIONS: Our study results indicate that diastolic dysfunction with a normal EF, in the absence of CAD and systolic dysfunction, has an excellent prognosis over a long period (5-6 years). |
| | |
Authors:
|
Jennifer Brady; Edward M Dwyer |
Related Documents
:
|
18157975 - Three-dimensional shape analysis of right ventricular remodeling in repaired tetralogy ... 19845815 - Limited response to cardiac resynchronization therapy in patients with concomitant righ... 15597235 - Reflected high-intensity motion signals: can this ultrasound phenomenon be used for ass... 11273995 - Regional wall motion and abnormalities of electrical depolarization and repolarization ... 19896095 - Recent developments in acute pancreatitis. 22089985 - Behçet disease: clinical features and management in a brazilian tertiary hospital. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Clinical cardiology Volume: 29 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-04-06 Completed Date: 2006-07-20 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 121-4 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, New Jersey Medical School/University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA. jenniferzimmer@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Chi-Square Distribution Coronary Angiography / methods Coronary Disease / radiography Diastole Female Heart Failure / diagnosis*, mortality*, therapy Humans Male Middle Aged Probability Prognosis Reference Values Retrospective Studies Risk Assessment Severity of Illness Index Stroke Volume / physiology* Survival Rate Time Factors Ventricular Dysfunction, Left / diagnosis*, mortality*, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characteristics and outcome of octogenarian population referred for myocardial perfusion imaging: co...
Next Document: Plasma adrenomedullin relation with Doppler-derived dP/dt in patients with congestive heart failure.