Document Detail

Prognosis for the patients with chronic hepatitis B.
MedLine Citation:
PMID:  10895548     Owner:  NLM     Status:  MEDLINE    
The purpose of the research was to determine the influence of the hepatitis B virus on the progression of the chronic liver disease. In the present paper, 127 patients who were followed up for five years and who had histologically verified chronic liver disease, are described. Fifty two of them were carriers of HBsAg, 75 patients were HBsAg negative, but had other markers typical for a previous infection of HBV in the sera. All the patients were nonalcoholics and no drug addicts. In the sera of these 127 patients markers of HBV were prospectively followed up: HBsAg, HBeAg, anti-HBs, anti-HBc, anti-HBe, HBVDNA, antiHCV for C virus and anti-D for D virus. It was proved by these investigations that HBV provokes very severe chronic hepatitis: CAH (chronic active hepatitis) and CH (cirrhosis hepatis). It was also proved that HBV replicated in 44.20% patients, namely, HBVDNA was positive in the sera of those patients. In 26.08% of such patients the mutant form of HBV was present. In spite of progressive liver disease and without any antiviral therapy all the patients with chronic HBV cirrhosis hepatis were, after five year-follow-up, in Child-Pugh A grade. It was found that the patients who were HBsAg negative, but had one or more markers of HBV positive in the sera, had also a severe chronic hepatitis. That group of patients remains our object of further research. The five-years follow-up of all these patients demonstrates that it is necessary to find out an efficient medicament against HBV chronic hepatitis. Obligatory vaccination of the risk population against virus B remains the only prevention against this severe disease.
V Colić-Cvrlje; S Naumovski-Mihalić; M Prskalo; A Colić; B Cvjeticanin; B Sabarić
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Collegium antropologicum     Volume:  24     ISSN:  0350-6134     ISO Abbreviation:  Coll Antropol     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-02     Completed Date:  2000-08-02     Revised Date:  2009-02-04    
Medline Journal Info:
Nlm Unique ID:  8003354     Medline TA:  Coll Antropol     Country:  CROATIA    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
University Hospital Merkur, Zagreb, Croatia.
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MeSH Terms
DNA, Viral
Hepatitis B Antibodies / blood
Hepatitis B Surface Antigens / blood
Hepatitis B virus / isolation & purification
Hepatitis B, Chronic / complications,  immunology,  pathology*,  virology
Hepatitis, Chronic / pathology
Liver Cirrhosis / etiology,  pathology
Middle Aged
Reg. No./Substance:
0/DNA, Viral; 0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens

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