Document Detail


Prognosis of patients with atherothrombotic disease: a prospective survey in a non-hospital setting.
MedLine Citation:
PMID:  16325285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Ischemic stroke, myocardial infarction and peripheral arterial disease are the clinical expression of a single underlying pathology. However, atherothrombotic diseases are often associated and little is known of the prognosis of these diseases taken as a whole. METHODS: The objective of the survey was to estimate the one-year occurrence of subsequent vascular events in patients with atherothrombotic disease. We measured the occurrence of myocardial infarction, ischemic stroke and cardiovascular death. Patients were enrolled by private practice physicians in a non-hospital setting. They had to present with at least one of myocardial infarction, ischemic non-embolic stroke, and peripheral arterial disease. The Kaplan-Meier method was used to determine the event-free survival and a multivariate analysis was used to assess predictors of cardiovascular events. RESULTS: 7783 eligible patients were enrolled by 3039 physicians. As a whole, 296 of 7783 patients (3.8%) experienced at least one ischemic event: 78 non-fatal myocardial infarction (26.4% of first events), 120 non-fatal stroke (40.5%) and 98 cardiovascular deaths (33.1%). For patients with a single location, the rate (crude percentage) of a first recurrent event was 2.9%, 4.8% and 3.2% in myocardial infarction, ischemic stroke and peripheral arterial disease; for patients with several locations the rate was 5.6%, 8.3%, 5.9%, respectively. But for patients with a single location, the one-year cumulative cardiovascular event rate observed separately in men or women, adjusted by age, was not statistically different whatever the location. CONCLUSIONS: Despite recent recommendations drawn from large clinical trials in secondary prevention, the risk of cardiovascular events remains very high in patients followed up in daily practice with a history of one or several atherothrombotic locations.
Authors:
Jean Ferrières; Jean-Pierre Cambou; Jean-Louis Gayet; Marie-Annick Herrmann; Alain Leizorovicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-01
Journal Detail:
Title:  International journal of cardiology     Volume:  112     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-10-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  302-7     Citation Subset:  IM    
Affiliation:
INSERM U 558, Department of Epidemiology, Toulouse, France. jean.ferrieres@cict.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Brain Ischemia / epidemiology*
Cardiovascular Diseases / mortality*
Coronary Artery Disease / epidemiology*
Female
Humans
Male
Middle Aged
Myocardial Infarction / epidemiology*
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Factors
Stroke / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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