Document Detail

Prognosis and outcome of pregnancies exposed to renin-angiotensin system blockers.
MedLine Citation:
PMID:  22903358     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To study pregnancy outcomes and fetal renal prognosis markers in cases of exposure to renin-angiotensin system blockers. METHODS: We conducted a retrospective study of a series of 21 patients exposed to blockers of the renin-angiotensin system during pregnancy. Two markers were prenatally studied, fetal serum β2-microglobulin and amniotic fluid volume. Poor renal prognosis evaluation was based on postnatal glomerular filtration rate or on the presence of renal histologic lesions. RESULTS: Of the 21 fetuses, only one had a normal postnatal renal function at birth (oligohydramnios regression and normal β2-microglobulin). All fetuses with persistent oligohydramnios or β2-microglobulin ≥5 mg/L presented an adverse renal outcome. CONCLUSION: Exposure to renin-angiotensin system blockers complicated by oligohydramnios is associated with a very poor outcome. We propose a prenatal management based on amniotic fluid volume monitoring and fetal serum β2-microglobulin. However, our preliminary results have to be confirmed by a larger study. © 2012 John Wiley & Sons, Ltd.
Emmanuel Spaggiari; Laurence Heidet; Gilles Grange; Fabien Guimiot; Sophie Dreux; Anne-Lise Delezoide; ; Françoise Muller
Related Documents :
24497208 - Pituitary tumors and pregnancy: the interplay between a pathologic condition and a phys...
16678328 - Interventions for leg edema and varicosities in pregnancy. what evidence?
12849848 - A case-control teratological study of vaginal natamycin treatment during pregnancy.
16453008 - Effect of magnitude and timing of maternal pregnancy blood lead (pb) levels on birth ou...
11535208 - Levonorgestrel-only emergency contraception: real-world tolerance and efficacy.
21195668 - Is the fertility treatment itself a risk factor for early pregnancy loss?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-18
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-6     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Developmental Biology, AP-HP, Robert Debré Hospital, Paris, France; University Paris 7 Diderot, Paris Sorbonne Cité, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Familial Mediterranean fever in Germany: epidemiological, clinical, and genetic characteristics of a...
Next Document:  Social housing and alcohol drinking in male-female pairs of prairie voles (Microtus ochrogaster).