Document Detail


Prognosis and outcome of pregnancies exposed to renin-angiotensin system blockers.
MedLine Citation:
PMID:  22903358     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To study pregnancy outcomes and fetal renal prognosis markers in cases of exposure to renin-angiotensin system blockers. METHODS: We conducted a retrospective study of a series of 21 patients exposed to blockers of the renin-angiotensin system during pregnancy. Two markers were prenatally studied, fetal serum β2-microglobulin and amniotic fluid volume. Poor renal prognosis evaluation was based on postnatal glomerular filtration rate or on the presence of renal histologic lesions. RESULTS: Of the 21 fetuses, only one had a normal postnatal renal function at birth (oligohydramnios regression and normal β2-microglobulin). All fetuses with persistent oligohydramnios or β2-microglobulin ≥5 mg/L presented an adverse renal outcome. CONCLUSION: Exposure to renin-angiotensin system blockers complicated by oligohydramnios is associated with a very poor outcome. We propose a prenatal management based on amniotic fluid volume monitoring and fetal serum β2-microglobulin. However, our preliminary results have to be confirmed by a larger study. © 2012 John Wiley & Sons, Ltd.
Authors:
Emmanuel Spaggiari; Laurence Heidet; Gilles Grange; Fabien Guimiot; Sophie Dreux; Anne-Lise Delezoide; ; Françoise Muller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-18
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-6     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Affiliation:
Developmental Biology, AP-HP, Robert Debré Hospital, Paris, France; University Paris 7 Diderot, Paris Sorbonne Cité, Paris, France. spaggiari2002@yahoo.fr.
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