Document Detail

Prognosis and outcome of neonates treated either with veno-arterial (VA) or veno-venous (VV) ECMO.
MedLine Citation:
PMID:  8647585     Owner:  NLM     Status:  MEDLINE    
A comparison was done between neonates requiring veno-arterial (VA) ECMO (too small jugular vein, inability to insert a 12 Fr double lumen catheter or cardio-circulatory instability) and neonates treated with veno-venous (VV) ECMO in the same period of time. From 1991-1995 ECMO was done in 48 neonates after failure of maximum conventional treatments, NO-inhalation and HFOV. 30/48 babies were treated with VV-ECMO, with a switch to VA-ECMO later on in 3 of them. In 18 infants VA-ECMO was installed primarily. Differences between the VA- and VV-ECMO group were: the OI was higher in the VV-treated babies (62 +/- 20 vs. 48 +/- 13, p < 0.03), as were birth weight (3385 +/- 570 vs. 2963 +/- 653 g, p < 0.04), gestational age (39.7 +/- 1.6 vs. 37.9 +/- 2.7 weeks, p < 0.01) and MAP (18.7 +/- 2.2 vs. 17.1 +/- 2.4 cm H2O, p < 0.05). Severe ICH's occurred more frequently in the VA-treated babies (29 vs. 7%, p < 0.05), the rate of other complications was equal. The mortality rates were 43% (VA) and 15% (VV), p < 0.05. About one third of neonatal ECMO candidates will be treated with VA-ECMO, even if the VV-ECMO technique is available. Need for VA-ECMO implies--due to a higher number of preterm babies and a greater severity of illness before ECMO--a higher incidence of ICH's and a higher mortality rate.
V Varnholt; P Lasch; J Sartoris; W Koelfen; W Kachel; C Lorenz; H Wirth
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  18     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-07-19     Completed Date:  1996-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  569-73     Citation Subset:  IM    
Kinderklinik, Universitäts-Klinikun, Mannheim, Germany.
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MeSH Terms
Birth Weight
Blood Pressure
Extracorporeal Membrane Oxygenation*
Gestational Age
Hypertension, Pulmonary / complications,  mortality,  therapy*
Infant, Newborn
Longitudinal Studies
Oxygen Consumption
Respiration, Artificial
Respiratory Insufficiency / etiology,  mortality,  therapy*
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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