Document Detail


Prognosis of oocyte donation cycles: a prospective comparison of the in vitro fertilization-embryo transfer cycles of recipients who used shared oocytes versus those who used altruistic donors.
MedLine Citation:
PMID:  18829002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To prospectively compare the prognosis of IVF-ET cycles using oocyte sharing vs. cycles using altruistic donors. DESIGN: Prospective cohort prognostic study. SETTING: University teaching hospital. PATIENT(S): A total of 353 consecutive infertile women with premature ovarian failure or diminished ovarian function. INTERVENTION(S): After receipt of institutional ethics approval, IVF-ET was performed with the use of either oocyte sharing (n = 220) or altruistic donors (n = 133). Continuous data (mean + SD [95% confidence interval]) were compared with Student's t test or Mann-Whitney test as appropriate; categoric data were compared with Fisher's exact test, odds ratios (OR), and relative risk (RR). Two-tailed P<.05 was considered significant. Logistic regression was used to adjust for confounding variables. MAIN OUTCOME MEASURE(S): The primary endpoint was clinical pregnancy. The secondary endpoints were E(2) dosage, endometrial thickness, fertilization, embryo quality, and rates of embryo cleavage, transfer, and implantation, positive beta-hCG, and biochemical, ectopic, and multiple pregnancy. RESULT(S): There was no statistically significant difference in clinical pregnancy rates (28.18% vs. 30.08%; OR 0.91 [0.49-1.67]; RR 1.07 [0.69-1.65]; adjusted OR 0.95 [0.51-1.78]). The mean E(2) dosage, endometrial thickness, fertilization rate, embryo score, embryo cleavage, number of embryos transferred, and rates of implantation, positive beta-hCG, and biochemical, ectopic, and multiple pregnancy were similar. CONCLUSION(S): The prognosis with use of shared oocytes is similar to that with altruistic donors.
Authors:
Olufunso A Oyesanya; Olufemi Olufowobi; Wendy Ross; Khaldoun Sharif; Masoud Afnan
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-09-30
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-31     Completed Date:  2009-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  930-6     Citation Subset:  IM    
Affiliation:
Assisted Conception Unit, Birmingham Women's Hospital, Birmingham, United Kingdom. Olufunso.Oyesanya@kellogg.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Embryo Transfer / methods*
Female
Fertilization in Vitro / methods*
Hospitals, University
Humans
Infertility, Female / diagnosis,  therapy
Logistic Models
Menstrual Cycle / physiology*
Oocyte Donation / methods*
Oocytes / physiology*
Pregnancy
Pregnancy Rate*
Prognosis
Prospective Studies
Tissue Donors*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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