| Prognosis of juvenile myoclonic epilepsy is related to endophenotypes. | |
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MedLine Citation:
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PMID: 21041102 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To investigate if phenotypic variations have prognostic implications in juvenile myoclonic epilepsy (JME). METHODS: Sixty-five consecutive JME patients had video-EEG recording and were followed for at least three years. Reflex traits were defined as seizures and/or EEG discharges induction by eye-closure, photic stimulation, language, praxis or calculation. Patients had psychiatric evaluation and answered to STAI (State-Trait Anxiety Inventory). Seizure control was classified according to Prasad et al. (2003).(24) Patients were divided into Group 1: good seizure control and Group 2: moderate or poor seizure control. Video-EEG/EEG evaluation was repeated in 21 patients. RESULTS: Forty of 65 (61.5%) patients reached good seizure control, 25 (38.5%) of whom became seizure free. Group 2 patients had longer epilepsy duration (13.9±9.0 vs. 8.7±8.2; p=0.019); higher prevalence of the combination of all three seizure types (72.0% vs. 30.0%; p=0.003); discharges in baseline EEG (56.0% vs. 22.5%; p=0.008); seizure recording (68% vs. 20%; p<0.001) and sensitivity to praxis (63.6% vs. 29.6%; p=0.023). Compared to seizure-free patients, those with persistent seizures presented younger age at epilepsy onset (12.6±3.33 years vs. 15.4±5.47 years; p=0.015); higher prevalence of personality disorders (25% vs. 4%; p=0.029); higher scores in STAI-T (45.9±11.31 vs. 36.6±11.43; p=0.011) and higher incidence of sensitivity to praxis (58.6% vs. 25.0%; p=0.04) and to language (53.8 vs. 16.7%; p=0.026) tasks. Repetition of EEG/video-EEG revealed a parallel evolution of reflex traits disappearance and seizure control. DISCUSSION: Clinical features and reflex traits have prognosis implications in JME. |
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Authors:
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Mirian S B Guaranha; Gerardo M de Araújo Filho; Kátia Lin; Laura M F F Guilhoto; Luis Otávio S F Caboclo; Elza Márcia T Yacubian |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-30 |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 20 ISSN: 1532-2688 ISO Abbreviation: Seizure Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: England |
Other Details:
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Languages: eng Pagination: 42-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurology and Neurosurgery, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil. mibit@ig.com.br |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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