| Prognosis in hypertrophic cardiomyopathy--echocardiographic follow-up and histopathological study. | |
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MedLine Citation:
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PMID: 2600996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 30 consecutive hypertrophic cardiomyopathy (HCM) patients who eventually died and 50 who survived, morphologic and functional changes in the heart during a follow-up period of an average of 3.9 years were echocardiographically evaluated. Echocardiographic indices were compared among 5 groups of patients with HCM, consisting of 4 groups of patients who eventually died (SD: 17 patients who suffered sudden death, ED: 4 who died of embolism, HF: 4 who died of congestive heart failure, NC: 5 who died of a noncardiac event) and 1 group of patients who survived with nondilated left ventricle (S: 50 patients). These indices at the last evaluation before death were compared with histopathological findings of left ventricles in 12 autopsied patients. At the initial evaluation ED and HF patients had a larger left ventricular end-diastolic dimension (LVDd), and HF patients had a smaller percent fractional shortening (%FS) and a slower normalized rapid filling rate (nRFR: mean rapid filling rate/LVEDV) than S patients, but these indices showed no differences between SD and S patients. During follow-up, no echocardiographic indices changed in S patients, but LVDd was increased and %FS and nRFR were decreased in SD and HF patients. Mean myocyte diameter and % area of disarray showed no differences among the 4 death groups. However, compared with NC, the other 3 groups, especially HF, had larger % area of massive fibrosis. The % area of massive fibrosis was correlated with LVDd (r = 0.80, p less than 0.005), %FS (r = -0.64, p less than 0.05), and nRFR (r = -0.95, p less than 0.001) at the last evaluation. These results suggested that echocardiographic follow-up was useful in predicting the progression of the myocardial lesion and the prognosis of HCM. |
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Authors:
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R Emoto; Y Yokota; H Fukuzaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 53 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1990-02-06 Completed Date: 1990-02-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1031-44 Citation Subset: IM |
Affiliation:
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1st Department of Internal Medicine, Kobe University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cardiomyopathy, Hypertrophic / diagnosis*, pathology, physiopathology Death, Sudden / etiology Echocardiography* Endomyocardial Fibrosis / pathology Female Follow-Up Studies Heart Ventricles / pathology, physiopathology Humans Male Middle Aged Myocardium / pathology* Predictive Value of Tests Prognosis Retrospective Studies |
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