Document Detail


Prognosis and expression of lambda light chains in solitary extramedullary plasmacytoma of the head and neck: two case reports and a literature review.
MedLine Citation:
PMID:  20233540     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two cases of extramedullary plasmacytoma (EMP) of the head and neck, an uncommon plasma cell neoplasm, were studied. Both patients had good outcomes and have been followed for 17 and 12 years without recurrence or systemic disease. In these two cases, the tumours measured were 4 cm and 0.3 cm, and both cases were positive for lambda light chain restriction on immunohistochemistry. Prognostic factors were considered, based on a review of EMP of the head and neck, including published reports and the authors' clinical experience. Of all plasma cell tumours, EMP has the best prognosis, especially when located in the head and neck region. Variation in the biological behaviour of EMP and the limited number of documented cases make it difficult to determine prognostic factors. Some series have found that age, tumour size, site of origin (extramedullary versus bone), grade, M-protein, light chains and radiotherapy dose all influence the outcome in EMP patients.
Authors:
H Y Liu; X M Luo; S H Zhou; Z J Zheng
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  38     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  282-8     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Zhejiang University, Hangzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Head and Neck Neoplasms / metabolism*,  pathology*,  therapy
Humans
Immunoenzyme Techniques
Immunoglobulin lambda-Chains / metabolism*
Middle Aged
Plasmacytoma / metabolism*,  pathology*,  therapy
Prognosis
Chemical
Reg. No./Substance:
0/Immunoglobulin lambda-Chains

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