Document Detail


Prognosis of diabetic gastroparesis--a 25-year evaluation.
MedLine Citation:
PMID:  23350946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate the prognosis of diabetic gastroparesis.
METHODS: Eighty-six patients with diabetes had measurements of gastric emptying of a mixed meal using a dual isotope test of solid and liquid meal components, mean blood glucose levels, HbA1c , upper gastrointestinal symptoms and autonomic nerve function performed in 1984-1989. These patients were followed up in 2011, after a mean period of ~25 years.
RESULTS: Of the 86 patients, gastric emptying of solid (the percentage remaining in the stomach at 100 min) was delayed in 35 (41%), and of liquid (the time taken for 50% of the liquid to empty) was delayed in 38 (44%). In 2011, 53 patients were known to be alive, 29 had died and four were lost to follow-up. In those who had died, both age at baseline (P < 0.001) and the score for autonomic nerve dysfunction (P < 0.001) were greater than those who were alive, while there was no difference in emptying of either the solid or liquid between the two groups. When patients with delayed gastric emptying were divided according to the median value ('delayed' and 'markedly delayed'), mortality tended to be greater in the 'markedly delayed' group for both solids (P = 0.12) and liquids (P = 0.09). Of the 82 patients who could be followed up, 23 of the 35 (66%) with delayed gastric emptying of solid and 25 of 38 (66%) with delayed gastric emptying of liquid were alive. After adjustment for age and autonomic dysfunction, there was no association between gastric emptying of either solid or liquid and death.
CONCLUSIONS: Over a period of ~25 years, diabetic gastroparesis is apparently not usually associated with a poor prognosis, or increased mortality.
ABBREVIATIONS: T100 min, the percentage remaining in the stomach at 100 mins; T50%, the time taken for 50% of the liquid to empty.
Authors:
J Chang; C K Rayner; K L Jones; M Horowitz
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-07
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  30     ISSN:  1464-5491     ISO Abbreviation:  Diabet. Med.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-16     Completed Date:  2013-12-02     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  e185-8     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Glucose / metabolism
Diabetes Mellitus, Type 1 / blood,  complications*,  physiopathology
Diabetes Mellitus, Type 2 / blood,  complications*,  physiopathology
Diabetic Neuropathies / blood,  etiology*,  physiopathology
Female
Follow-Up Studies
Gastric Emptying
Gastroparesis / blood,  etiology*,  physiopathology
Hemoglobin A, Glycosylated / metabolism
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Risk Assessment
Time Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human

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