| Prognosis of coronary arterial lesions in Kawasaki disease treated without intravenous immunoglobulin. | |
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MedLine Citation:
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PMID: 9066187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From 1981 to 1989, a total of 86 consecutive patients with definite Kawasaki disease who received aspirin but not intravenous immunoglobulin (IVIG) therapy during the acute stage were studied. Thirty-eight of them (44%) had coronary arterial lesion (CAL) on initial two dimensional echocardiograms. Of them, 21 (56%) had ectatic coronary changes, 13 (34%) had small to large coronary aneurysms (diameter < or = 8 mm) and 4 (10%), giant coronary aneurysms (diameter > 8 mm). Patients with CAL had, in the acute stage, a longer duration of fever (p < 0.01), higher maximum platelet counts (p < 0.05) and a higher one-hour erythrocyte sedimentation rate (< 0.01) than those without. Males were associated with a higher incidence of aneurysmal dilatation of the CAL. By actuarial event-free analysis, more than half of the ectatic coronary lesions regressed within two months of onset, and 86% became normal on echocardiograms within a two-year follow-up period. Ectatic lesions had a significantly higher chance of regression than aneurysmal lesions (p < 0.01). Furthermore, none of the giant aneurysms regressed (p < 0.05, as compared with those coronary aneurysms smaller than 8 mm in diameter). It was concluded that coronary arterial lesions occurred in a substantial number of Chinese children with Kawasaki disease who received only aspirin therapy. Regression of the lesions was related to their size and morphology. |
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Authors:
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K T Tzen; M H Wu; J K Wang; H C Lue; C Y Lee; S C Chien |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui Volume: 38 ISSN: 0001-6578 ISO Abbreviation: Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi Publication Date: 1997 Jan-Feb |
Date Detail:
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Created Date: 1997-04-03 Completed Date: 1997-04-03 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 16210470R Medline TA: Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi Country: TAIWAN |
Other Details:
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Languages: eng Pagination: 32-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Coronary Disease / etiology* Female Humans Immunoglobulins, Intravenous / therapeutic use* Infant Male Mucocutaneous Lymph Node Syndrome / complications, therapy* Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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