Document Detail

Prognosis of coronary arterial lesions in Kawasaki disease treated without intravenous immunoglobulin.
MedLine Citation:
PMID:  9066187     Owner:  NLM     Status:  MEDLINE    
From 1981 to 1989, a total of 86 consecutive patients with definite Kawasaki disease who received aspirin but not intravenous immunoglobulin (IVIG) therapy during the acute stage were studied. Thirty-eight of them (44%) had coronary arterial lesion (CAL) on initial two dimensional echocardiograms. Of them, 21 (56%) had ectatic coronary changes, 13 (34%) had small to large coronary aneurysms (diameter < or = 8 mm) and 4 (10%), giant coronary aneurysms (diameter > 8 mm). Patients with CAL had, in the acute stage, a longer duration of fever (p < 0.01), higher maximum platelet counts (p < 0.05) and a higher one-hour erythrocyte sedimentation rate (< 0.01) than those without. Males were associated with a higher incidence of aneurysmal dilatation of the CAL. By actuarial event-free analysis, more than half of the ectatic coronary lesions regressed within two months of onset, and 86% became normal on echocardiograms within a two-year follow-up period. Ectatic lesions had a significantly higher chance of regression than aneurysmal lesions (p < 0.01). Furthermore, none of the giant aneurysms regressed (p < 0.05, as compared with those coronary aneurysms smaller than 8 mm in diameter). It was concluded that coronary arterial lesions occurred in a substantial number of Chinese children with Kawasaki disease who received only aspirin therapy. Regression of the lesions was related to their size and morphology.
K T Tzen; M H Wu; J K Wang; H C Lue; C Y Lee; S C Chien
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui     Volume:  38     ISSN:  0001-6578     ISO Abbreviation:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-04-03     Completed Date:  1997-04-03     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  16210470R     Medline TA:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
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MeSH Terms
Child, Preschool
Coronary Disease / etiology*
Immunoglobulins, Intravenous / therapeutic use*
Mucocutaneous Lymph Node Syndrome / complications,  therapy*
Reg. No./Substance:
0/Immunoglobulins, Intravenous

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