Document Detail

Prognosis of upper eyelid epiblepharon repair in down syndrome.
MedLine Citation:
PMID:  20643394     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the recurrence rate after upper eyelid epiblepharon repair in patients with Down syndrome.
DESIGN: Retrospective, observational study.
METHODS: Total of 578 Korean children (21 with Down syndrome patients, 557 with non-Down syndrome patients), who had undergone epiblepharon repair and were followed up for more than 2 months, were included in this study. The recurrence rate was compared between two groups at 2, 6 months after surgery. Recurrence was defined as the re-appearance of cilia touching to cornea. The recurrence rate was also analyzed according to whether patients had undergone concomitant z-medial epicanthoplasty or not.
RESULTS: Lower eyelid epiblepharon repair was performed on 22 eyelids of Down syndrome patients, and 1072 eyelids of non-Down syndrome patients. At 3 months after surgery, the recurrence rate was not significantly different between two groups (P = 1.00). Upper eyelid epiblepharon was repaired on 40 eyelids of Down syndrome patients, and 204 eyelids in non-Down syndrome patients. At 2 and 6 months after surgery, the recurrence rate was significantly higher in Down syndrome patients (27.5% and 29.4%) than non-Down syndrome patients (3.4% and 4.6%) (P = 0.000, P = 0.004, respectively). The recurrence rate of upper eyelid epiblepharon repair was not affected in both groups whether Z-epicanthoplasty was combined or not (P = 1.00 in both groups).
CONCLUSIONS: In Down syndrome patients, the recurrence rate after upper eyelid epiblepharon repair was higher than non-Down syndrome patients. The effect of combined Z-medial epicanthoplasty was limited in both groups.
Kyoung Min Lee; Ho Kyung Choung; Nam Ju Kim; Min Joung Lee; Kyeong-Wook Lee; Sang In Khwarg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  150     ISSN:  1879-1891     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2010-10-06     Revised Date:  2011-07-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  476-480.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
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MeSH Terms
Down Syndrome / complications*
Eye Abnormalities / diagnosis,  surgery*
Eyelids / abnormalities*
Follow-Up Studies
Ophthalmologic Surgical Procedures*
Retrospective Studies
Comment In:
Am J Ophthalmol. 2011 Jun;151(6):1104; author reply 1104-5   [PMID:  21616215 ]

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