Document Detail


Prognosis of minimally invasive carcinoma arising in mucinous cystic neoplasms of the pancreas.
MedLine Citation:
PMID:  23388125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although patients with surgically resected noninvasive mucinous cystic neoplasms (MCNs) of the pancreas are cured, the behavior of surgically resected minimally invasive adenocarcinomas arising in MCN has not been well established. We report 16 surgically resected MCNs with minimal invasion defined as unifocal or multifocal microscopic invasive adenocarcinoma confined to the ovarian stroma of the MCN without capsular or pancreatic parenchymal invasion. Pathologic findings were correlated with patient demographics, type of surgery, and long-term follow-up. Our study included 15 women and 1 man ranging in age from 25 to 66 years. The patients were followed up for a mean of 48.6 months (range, 12 to 148 mo). The MCNs ranged in size from 3.5 to 25 cm and were all located in the body/tail of the gland. Lymphovascular invasion was not identified in any of the cases, and all lymph nodes were negative for tumor. Ten neoplasms had unifocal invasion, whereas 6 had multifocal invasion. Twelve of the neoplasms were partially submitted for microscopic examination, whereas 4 were submitted entirely. Only 1 of the 16 minimally invasive MCNs recurred, and that tumor had been lighlty sampled pathologically. Our study demonstrates that the majority of patients with minimally invasive adenocarcinoma arising in MCNs are cured by surgery, particularly if the neoplasms are completely examined histologically.
Authors:
Gloria H Lewis; Huamin Wang; Andrew M Bellizzi; Alison P Klein; Frederic B Askin; Lauren Ende Schwartz; Richard D Schulick; Christopher L Wolfgang; John L Cameron; Eileen M O'Reilly; Kenneth H Yu; Ralph H Hruban
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  37     ISSN:  1532-0979     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-13     Completed Date:  2013-05-07     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cystadenocarcinoma, Mucinous / diagnosis*,  surgery
Female
Humans
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Pancreas / pathology*
Pancreatic Neoplasms / diagnosis*,  surgery
Prognosis
Treatment Outcome
Grant Support
ID/Acronym/Agency:
P50 CA062924/CA/NCI NIH HHS; P50CA062924/CA/NCI NIH HHS
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