Document Detail


Prognosis of EEG findings in infancy.
MedLine Citation:
PMID:  22659713     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: : To determine how specific early EEG abnormalities correlate with clinical outcome on long-term follow-up for neurological and epilepsy outcomes. Our aim was to revisit how early EEG abnormalities should be weighed for prognosis.
METHODS: : This is a retrospective study of 358 infants who had EEGs taken between 3 and 12 months of age and subsequent clinical assessment between 4 to 18 years of age.
RESULT: : Of the 358 infants, 215 had unfavorable neurological outcome (UNO), and 234 had epilepsy on follow-up. Breakdown: 117 had major abnormal EEG background of which 86% had UNO and 75% had epilepsy. One hundred had abnormal sleep potentials of which 89% had UNO and 80% had epilepsy. One hundred seventy-five had interictal epileptiform activity of which 80% had UNO and epilepsy. Sixty had ictal epileptiform activity of which 90% had UNO and 86% had epilepsy. One hundred ninety-two had markedly abnormal overall EEG impression of which 80% had UNO and 79% had epilepsy.
CONCLUSIONS: : Occurrence of significant EEG abnormalities in the first year was clearly associated with UNO and epilepsy. Current views that certain EEG abnormalities (e.g., interictal spike) may have little prognostic significance would need to be revisited.
Authors:
Salah Almubarak; Peter K H Wong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  29     ISSN:  1537-1603     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-8     Citation Subset:  IM    
Affiliation:
*Department of Clinical Neurophysiology, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia †Department of Diagnostic Neurophysiology, British Columbia Children's Hospital, Vancouver, Canada ‡Division of Neurology, University of British Columbia, Vancouver, Canada.
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