Document Detail

Proglycogen, macroglycogen, glucose, and glucose-6-phosphate concentrations in skeletal muscles of horses with polysaccharide storage myopathy performing light exercise.
MedLine Citation:
PMID:  16948606     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine concentrations of proglycogen (PG), macroglycogen (MG), glucose, and glucose-6-phosphate (G-6-P) in skeletal muscle of horses with polysaccharide storage myopathy (PSSM) before and after performing light submaximal exercise. ANIMALS: 6 horses with PSSM and 4 control horses. PROCEDURES: Horses with PSSM completed repeated intervals of 2 minutes of walking followed by 2 minutes of trotting on a treadmill until muscle cramping developed. Four untrained control horses performed a similar exercise test for up to 20 minutes. Serum creatine kinase (CK) activity was measured before and 4 hours after exercise. Concentrations of total glycogen (G(t)), PG, MG, G-6-P, free glucose, and lactate were measured in biopsy specimens of gluteal muscle obtained before and after exercise. RESULTS: Mean serum CK activity was 26 times higher in PSSM horses than in control horses after exercise. Before exercise, muscle glycogen concentrations were 1.5, 2.2, and 1.7 times higher for PG, MG, and G(t), respectively, in PSSM horses, compared with concentrations in control horses. No significant changes in G(t), PG, MG, G-6-P, and lactate concentrations were detected after exercise. However, free glucose concentrations in skeletal muscle increased significantly in PSSM horses after exercise. CONCLUSIONS AND CLINICAL RELEVANCE: Analysis of the results suggests that glucose uptake in skeletal muscle is augmented in horses with PSSM after light exercise. There is excessive storage of PG and MG in horses with PSSM, and high concentrations of the 2 glycogen fractions may affect functional interactions between glycogenolytic and glycogen synthetic enzymes and glycosomes.
Johan T Bröjer; Birgitta Essén-Gustavsson; Erin J Annandale; Stephanie J Valberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  67     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1589-94     Citation Subset:  IM    
Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agriculture Sciences, 75007 Uppsala, Sweden.
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MeSH Terms
Biopsy / veterinary
Creatine Kinase / blood
Glucose / metabolism
Glucose-6-Phosphate / metabolism
Glycogen / metabolism
Glycogen Storage Disease / metabolism,  veterinary*
Horse Diseases / metabolism*
Lactic Acid / metabolism
Muscle, Skeletal / metabolism*
Muscular Diseases / metabolism,  veterinary*
Physical Conditioning, Animal / physiology*
Reg. No./Substance:
50-21-5/Lactic Acid; 50-99-7/Glucose; 56-73-5/Glucose-6-Phosphate; 9005-79-2/Glycogen; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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