Document Detail

Proglumide has access to brain and antagonizes the central satiety effect of cholecystokinin octapeptide in the dog.
MedLine Citation:
PMID:  3651819     Owner:  NLM     Status:  MEDLINE    
Intra-third cerebroventricularly administered cholecystokinin octapeptide (CCK-8) decreased food intake through central mechanisms in the dog. Proglumide, administered intravenously, did enter into cerebrospinal (ventricular) fluid, and partially, but significantly, reversed this effect. CR1409, one of the newly synthesized glutaramic derivatives, blocked CCK-8-induced satiety more strongly than proglumide. These results indicate that systemic proglumide and CR1409 result in antagonism of the central CCK receptor for satiety in the dog.
A Inui; T Inoue; N Sakatani; M Oya; H Morioka; S Baba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  417     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-11-20     Completed Date:  1987-11-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  355-9     Citation Subset:  IM    
Second Department of Internal Medicine, School of Medicine, Kobe University, Japan.
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MeSH Terms
Blood-Brain Barrier / drug effects*
Brain / drug effects,  physiology*
Dose-Response Relationship, Drug
Drinking Behavior / drug effects
Feeding Behavior / drug effects
Glutamine / analogs & derivatives*
Infusions, Intravenous
Injections, Intraventricular
Proglumide / analogs & derivatives,  metabolism*,  pharmacology
Satiation / drug effects*
Satiety Response / drug effects*
Sincalide / administration & dosage,  pharmacology*
Time Factors
Reg. No./Substance:
25126-32-3/Sincalide; 56-85-9/Glutamine; 6620-60-6/Proglumide; 97964-56-2/lorglumide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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