| Progestins induce catalase activities in breast cancer cells through PRB isoform: correlation with cell growth inhibition. | |
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MedLine Citation:
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PMID: 19383545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive oxygen species (ROS) have been suggested to participate in tumor emergence due to their mitogenic and apoptotic signaling, and as contributors to DNA structural damage. Here we report that progesterone and various synthetic steroids with progestin potencies (norethisterone acetate, MPA, and Tibolone) counteract cell growth induced by hydrogen peroxide (H(2)O(2)), through a potent induction of catalase activities, in breast cancer cells and normal human epithelial breast cells. At physiological concentrations, progesterone and the pure progestin, Org2058, displayed the most potent H(2)O(2) detoxification ability suggesting its effect was characteristic of its progestin potency. We also report on the enhancement of catalase activities by progesterone receptor isoform B (PRB), as determined from experiments using antiprogestins and MDA-MB-231, cells engineered for the selective expression of progesterone receptor isoform A or B. The potent action of progesterone on catalase activities indicates its contribution to a beneficial role in breast cell homeostasis. |
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Authors:
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Emile Petit; Aurélie Courtin; Helenius J Kloosterboer; William Rostène; Patricia Forgez; Anne Gompel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-19 |
Journal Detail:
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Title: The Journal of steroid biochemistry and molecular biology Volume: 115 ISSN: 1879-1220 ISO Abbreviation: J. Steroid Biochem. Mol. Biol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-08 Completed Date: 2009-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9015483 Medline TA: J Steroid Biochem Mol Biol Country: England |
Other Details:
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Languages: eng Pagination: 153-60 Citation Subset: IM |
Affiliation:
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INSERM-UPMC Univ Paris 06, UMRS 938, Hôpital Saint-Antoine, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast
/
cytology,
physiology Breast Neoplasms* / metabolism, pathology Catalase / genetics, metabolism* Cell Line, Tumor* / drug effects, metabolism Estrogen Receptor Modulators / metabolism, pharmacology Female Humans Hydrogen Peroxide / metabolism, pharmacology Norpregnenes / metabolism, pharmacology Oxidants / metabolism, pharmacology Progesterone / chemistry, metabolism, pharmacology Progestins / chemistry, metabolism, pharmacology* Reactive Oxygen Species / metabolism Receptors, Progesterone / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Receptor Modulators; 0/Norpregnenes; 0/Oxidants; 0/Progestins; 0/Reactive Oxygen Species; 0/Receptors, Progesterone; 0/progesterone receptor B; 5630-53-5/tibolone; 57-83-0/Progesterone; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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