| Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats. | |
| | |
MedLine Citation:
|
PMID: 17028418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The progesterone (P(4)) metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), acts in the midbrain ventral tegmental area (VTA) to modulate the intensity and duration of lordosis. 3alpha,5alpha-THP can also have anti-anxiety and anti-stress effects in part through actions in the hippocampus. Separate reports indicate that manipulating 3alpha,5alpha-THP levels in the VTA or hippocampus respectively can influence lordosis and affective behavior. 3alpha,5alpha-THP levels can also be altered by behavioral experiences, such as mating or swim stress. Whether endogenous levels of 3alpha,5alpha-THP modulate and/or are increased in response to affective and/or reproductively-relevant behaviors was investigated. METHODS: In Experiment 1, rats in behavioral estrus or diestrus were individually tested sequentially in the open field, elevated plus maze, partner preference, social interaction, and paced mating tasks and levels of 17beta-estradiol (E(2)), P(4), dihydroprogesterone (DHP), and 3alpha,5alpha-THP in serum, midbrain, hippocampus, diencephalon, and cortex were examined. In Experiments 2 and 3, rats in behavioral estrus or diestrus, were individually tested in the battery indicated above, with, or without, paced mating and tissues were collected immediately after testing for later assessment of endocrine measures. RESULTS: In Experiment 1, behavioral estrous, compared to diestrous, rats demonstrated more exploratory, anti-anxiety, social, and reproductive behaviors, and had higher levels of E(2) and progestins in serum, midbrain, hippocampus, diencephalon, and cortex. In Experiment 2, in midbrain and hippocampus, levels of 3alpha,5alpha-THP and its precursor DHP were increased among rats in behavioral estrus that were mated. In diencephalon, and cortex, DHP levels were increased by mating. In Experiment 3, in midbrain, levels of 3alpha,5alpha-THP and its precursor DHP were increased among diestrous rats that were tested in the behavioral battery with mating as compared to those tested in the behavioral battery without mating. CONCLUSIONS: Increased levels of 3alpha,5alpha-THP in behavioral estrus versus diestrous rats are associated with enhanced exploratory, anti-anxiety, social, and reproductive behaviors. Rats in behavioral estrus that are mated have further increases in 3alpha,5alpha-THP and/or DHP levels in midbrain, hippocampus, diencephalon, and cortex than do non-mated rats in behavioral estrus, whereas diestrous rats only show 3alpha,5alpha-THP increases in midbrain in response to behavioral testing that included mating. |
| | |
Authors:
|
Cheryl A Frye; Madeline E Rhodes |
Related Documents
:
|
7696138 - Effects of stress on defensive aggression and dominance in a water competition test. 12213498 - Acute fasting decreases sexual receptivity and neural estrogen receptor-alpha in female... 19447128 - Progestogens and estrogen influence impulsive burying and avoidant freezing behavior of... 17651428 - Individual differences in response to novelty predict prefrontal cortex dopamine transp... 2916078 - Effects of adjuvant arthritis on copper, zinc, and iron metabolism in the rat. 1536148 - Uptake of transferrin-bound and nontransferrin-bound iron by reticulocytes from the bel... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2006-10-04 |
Journal Detail:
|
Title: Neuroendocrinology Volume: 83 ISSN: 0028-3835 ISO Abbreviation: Neuroendocrinology Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-12-06 Completed Date: 2007-01-22 Revised Date: 2013-04-01 |
Medline Journal Info:
|
Nlm Unique ID: 0035665 Medline TA: Neuroendocrinology Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 336-47 Citation Subset: IM |
Affiliation:
|
Department of Psychology, University at Albany-SUNY, Albany, NY 12222 , USA. cafrye@albany.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anxiety / metabolism Brain / metabolism Copulation / physiology* Diestrus / metabolism* Estradiol / metabolism Estrus / metabolism* Exploratory Behavior / physiology* Female Mesencephalon / metabolism* Pregnanolone / metabolism* Progestins / metabolism Rats Rats, Long-Evans Reproduction / physiology Social Behavior |
| Grant Support | |
ID/Acronym/Agency:
|
MH06769801/MH/NIMH NIH HHS; R01 MH067698/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Progestins; 128-20-1/Pregnanolone; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Friedrich Feyrter: a precise intellect in a diffuse system.
Next Document: Prednisone blunts airway neutrophilic inflammatory response due to ozone exposure in asthmatic subje...