| Progesterone:estradiol ratios at implantation in ongoing pregnancies, abortions, and nonconception cycles resulting from ovulation induction. | |
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MedLine Citation:
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PMID: 2379624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to compare progesterone (P):estradiol (E2) ratios after ovulation induction at the time of implantation in cycles resulting in ongoing pregnancies or abortions and in nonconception cycles. Material included 43 stimulated conception cycles, 29 with human menopausal gonadotropins (hMG) and human chorionic gonadotropins (hCG), 14 with clomiphene citrate (CC) with or without hCG, and 28 nonconception cycles (13 hMG and hCG, 15 CC with or without hCG). Midluteal P and E2 were measured and expressed in ng/mL. There were no differences in P:E2 ratios (mean +/- SE) for ongoing pregnancies after hMG and hCG (n = 20, 112.6 +/- 14.9), CC and hCG (n = 6, 97.0 +/- 15.9), or CC alone (n = 5, 96.2 +/- 25.5), and the data were pooled. Progesterone:estradiol ratios in 31 ongoing pregnancies and 28 nonconception cycles were 107.0 +/- 10.7 and 115.2 +/- 12.5, respectively, both significantly higher than in 12 abortions (64.5 +/- 13.2). In conclusion: (1) P:E2 ratios at the time of implantation were similar after CC with or without hCG and hMG and hCG treatment; (2) high luteal P:E2 ratio was associated with ongoing pregnancies; and (3) lower P:E2 ratio was seen in cycles leading to spontaneous abortion. |
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Authors:
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V M Maclin; E Radwanska; Z Binor; W P Dmowski |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 54 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-09-07 Completed Date: 1990-09-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 238-44 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Rush Medical College, Chicago, Illinois 60612. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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blood* Adult Embryo Implantation* Estradiol / blood* Female Humans Menstrual Cycle / blood* Pregnancy / blood* Pregnancy Trimester, First Progesterone / blood* |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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