Document Detail

Progesterone treatment and the progress of early pregnancy reduce desmoglein 1&2 staining along the lateral plasma membrane in rat uterine epithelial cells.
MedLine Citation:
PMID:  15530549     Owner:  NLM     Status:  MEDLINE    
Uterine epithelium undergoes dramatic changes during early pregnancy in preparation for implantation. We have studied distribution patterns of the desmosomal marker, desmoglein 1&2, in rat uterine epithelial cells during early pregnancy as well as in hormonally stimulated ovariectomised animals. On day 1 of pregnancy as well as in oestradiol treated rats, desmoglein 1&2 staining was localized along the entire length of the lateral plasma membrane. By day 3 and on subsequent days of pregnancy as well as in ovariectomised animals treated with progesterone alone or in combination with oestradiol, desmoglein 1&2 staining was concentrated at the apical portion of the lateral plasma membrane. We suggest that the reorganisation of these desmosomal cadherins is an important component of uterine epithelial receptivity and this relocation is under the control of the ovarian hormone progesterone.
Amanda M Preston; Laura A Lindsay; Christopher R Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta histochemica     Volume:  106     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-08     Completed Date:  2005-03-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
Department of Anatomy and Histology, The University of Sydney, NSW 2006, Australia.
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MeSH Terms
Cadherins / metabolism*
Cell Membrane / drug effects,  metabolism*
Cytoskeletal Proteins / metabolism*
Desmoglein 1
Drug Therapy, Combination
Epithelial Cells / drug effects,  metabolism*
Estradiol / pharmacology
Fluorescent Antibody Technique, Indirect
Injections, Subcutaneous
Pregnancy / metabolism*
Progesterone / administration & dosage,  pharmacology*
Rats, Wistar
Uterus / drug effects,  metabolism*
Reg. No./Substance:
0/Cadherins; 0/Cytoskeletal Proteins; 0/Desmoglein 1; 0/Desmogleins; 0/Desmoplakins; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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