Document Detail


Progesterone regulation of primordial follicle assembly in bovine fetal ovaries.
MedLine Citation:
PMID:  19747959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fertility in mammals is dependant on females having an adequate primordial follicle pool to supply oocytes for fertilization. The formation of primordial follicles is called ovarian follicular assembly. In rats and mice progesterone and estradiol have been shown to inhibit follicle assembly with assembly occurring after birth when the pups are removed from the high-steroid maternal environment. In contrast, primordial follicle assembly in other species, such as cattle and humans, occurs during fetal development before birth. The objective of the current study is to determine if progesterone levels regulate primordial follicle assembly in fetal bovine ovaries. Ovaries and blood were collected from bovine fetuses. Interestingly, ovarian progesterone and estradiol concentrations were found to decrease with increasing fetal age and correlated to increased primordial follicle assembly. Microarray analysis of fetal ovary RNA suggests that progesterone membrane receptor and estrogen nuclear receptor are expressed. Treatment of fetal bovine ovary cultures with a higher progesterone concentration significantly decreased primordial follicle assembly. Observations indicate that progesterone affects ovarian primordial follicle assembly in cattle, as it does in rats and mice.
Authors:
Eric E Nilsson; Michael K Skinner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-09-10
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  313     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-16     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  9-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Estradiol / metabolism
Female
Fetus* / anatomy & histology,  drug effects
Gene Expression Profiling
Mice
Microarray Analysis
Oocytes / cytology,  metabolism
Organ Culture Techniques
Ovarian Follicle / cytology,  drug effects*,  physiology*
Progesterone / metabolism,  pharmacology*
Rats
Grant Support
ID/Acronym/Agency:
R01 ES012974/ES/NIEHS NIH HHS; R01 HD048898/HD/NICHD NIH HHS; R01 HD048898-04/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
4G7DS2Q64Y/Progesterone; 4TI98Z838E/Estradiol
Comments/Corrections

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