Document Detail

Progesterone for recurrent miscarriage: truth and deceptions.
MedLine Citation:
PMID:  17964858     Owner:  NLM     Status:  MEDLINE    
Recurrent miscarriage is known to affect 0.5-2% of pregnant women, and the standard investigative protocol fails to identify a specific cause in 50% of cases. Progesterone, a key hormone in pregnancy maintenance, has been used to support early pregnancy for decades. A growing body of considerable evidence indicates that in addition to women with luteal phase defects, women with idiopathic recurrent miscarriage may benefit from progestogen treatment, as progesterone has been shown to be an essential immunomodulatory agent in early pregnancy. It plays a critical role in the expression, modulation and inhibition of various growth factors, cytokines, cell adhesion molecules and decidual proteins. Some studies have revealed a remarkable improvement in pregnancy outcome after progestogen supplementation in women suffering from recurrent miscarriage. As most studies on this topic are of unsufficient statistical power, further research on the efficacy of progestogen treatment in affected women is required.
Katharina T Walch; Johannes C Huber
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-10-29
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  22     ISSN:  1521-6934     ISO Abbreviation:  Best Pract Res Clin Obstet Gynaecol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  375-89     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A - 1090 Vienna, Austria.
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MeSH Terms
Abortion, Habitual / etiology,  prevention & control*
Evidence-Based Medicine
Immune Tolerance
Immunity, Cellular / drug effects
Immunosuppressive Agents / therapeutic use*
Pregnancy Outcome
Progesterone / therapeutic use*
Reg. No./Substance:
0/Immunosuppressive Agents; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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