| Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility. | |
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MedLine Citation:
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PMID: 10518569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thymocyte development is reported to be inhibited by pregnancy, although the impact of this effect on fertility is unknown. We demonstrate, using progesterone receptor null mutant mice, that the inhibitory effects of pregnancy hormones on T cell development require the presence of functional progesterone receptor (PR). A combination of hysterectomy, thymic immunohistochemistry, and transplant studies reveals that local expression of PR in thymic stromal cells is specifically required for thymic involution to occur. These cells, under the influence of progesterone, block T cell development at the early pre-T cell (CD3(-)CD44(+) CD25(+)) stage of development via a paracrine mechanism. In addition, age-related thymic involution is shown to occur by a separate PR-independent mechanism. Finally, pregnancy studies with thymic transplants from progesterone receptor null mutant mice to wild-type female recipients demonstrate that thymic stromal PR is required for normal fertility. Together, these observations provide evidence for a PR-dependent paracrine mechanism that blocks very early T cell lymphopoiesis during pregnancy and is essential for normal fertility. |
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Authors:
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T A Tibbetts; F DeMayo; S Rich; O M Conneely; B W O'Malley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 96 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-11-24 Completed Date: 1999-11-24 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 12021-6 Citation Subset: IM |
Affiliation:
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Baylor College of Medicine, Department of Cell Biology, 1 Baylor Plaza, Houston, TX 77040, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Female Fertility* Flow Cytometry Mice Mice, Inbred Strains Organ Size Pregnancy Pregnancy, Animal / physiology* Receptors, Progesterone / physiology* T-Lymphocytes / physiology Thymus Gland / anatomy & histology, growth & development, physiology* Transplantation Chimera |
| Grant Support | |
ID/Acronym/Agency:
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HD07857/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Progesterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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