Document Detail


Progesterone-prostaglandin balance influences lymphocyte function in relation to pregnancy.
MedLine Citation:
PMID:  6581738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of progesterone and prostaglandin F2 alpha on cytotoxic activity of lymphocytes was investigated. Thirty-three pregnant women with a clinical diagnosis of threatened premature labour were treated with the prostaglandin synthesis inhibitor acetylsalicylic acid (2.7 gm/day) for 1 week. Cytotoxic activity of the lymphocytes significantly decreased while their progesterone binding capacity increased by the end of the treatment. Ten healthy pregnant women received a single 15 mg dose of prostaglandin F2 alpha for pregnancy termination. One day after prostaglandin administration lymphocytes showed significantly higher cytotoxic activity and lower progesterone binding capacity than before. Lymphocytes of 44 healthy nonpregnant volunteers were preincubated with prostaglandin F2 alpha and/or progesterone. Prostaglandin F2 alpha (8 nmole) significantly decreased cytotoxic activity of 4 X 10(6) lymphocytes. In the presence of progesterone prostaglandin F2 alpha failed to stimulate lymphocytes.
Authors:
J Szekeres-Barthó; V Csernus; J Hadnagy; A S Pacsa
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction     Volume:  4     ISSN:  0271-7352     ISO Abbreviation:  Am J Reprod Immunol     Publication Date:    1983 Oct-Nov
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111069     Medline TA:  Am J Reprod Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Threatened / immunology
Aspirin / pharmacology
Cytotoxicity, Immunologic / drug effects
Dinoprost
Female
Humans
Lymphocytes / drug effects*,  immunology,  metabolism
Pregnancy*
Progesterone / blood,  pharmacology*
Prostaglandins F / pharmacology*
Chemical
Reg. No./Substance:
0/Prostaglandins F; 50-78-2/Aspirin; 551-11-1/Dinoprost; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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