Document Detail

Progesterone for the luteal support of assisted reproductive technologies: clinical options.
MedLine Citation:
PMID:  10928425     Owner:  NLM     Status:  MEDLINE    
The role of progesterone in luteal support in assisted reproductive technologies (ART) is reviewed. There is insufficient data in ART treatment without gonadotrophin-releasing hormone (GnRH) analogues, to prove the necessity for luteal phase support using progesterone. Prospective studies have shown that ART cycles using GnRH analogues need to be supplemented. GnRH antagonists could have some adverse effects on the luteal phase. So far, no prospective randomized comparative study has been performed to investigate the necessity for luteal phase support when antagonists are used in ART cycles. Clinical outcome data (pregnancy and abortion rates) show similar success rates for human chorionic gonadotrophin (HCG) or progesterone supplementation. A major disadvantage of using HCG is the risk of maintaining or enhancing ovarian hyperstimulation syndrome. Of the several routes of administration of progesterone, the vaginal route is preferred because of its ease of use, reduced side-effects and, most importantly, the first uterine pass effect.
C Posaci; J Smitz; M Camus; K Osmanagaoglu; P Devroey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15 Suppl 1     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-22     Completed Date:  2000-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  129-48     Citation Subset:  IM    
Centre for Reproductive Medicine, Dutch-speaking Brussels Free University, Belgium.
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MeSH Terms
Biological Availability
Endometrium / drug effects,  physiology*
Gonadotropin-Releasing Hormone / agonists
Luteal Phase / drug effects*
Ovulation Induction / methods*
Progesterone / administration & dosage,  adverse effects,  pharmacology*
Reproductive Techniques*
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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