| Progesterone-like effects of estradiol on reproductive behavior and hypothalamic progestin receptors in the female rat. | |
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MedLine Citation:
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PMID: 6540375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the rat estrous cycle, estradiol (E2) and progesterone (P) synergize to activate reproductive behavior. However, receptivity and proceptivity can be elicited by E2 alone in ovariectomized (OVX) animals, particularly when E2 doses are high. The purpose of this study was to determine the neuroendocrine mechanism by which E2 elicits P-dependent reproductive behavior. Adult OVX females received estrogen treatment for 72 h, which consisted of 5 mm Silastic capsules containing 100% E2 or 10% E2, or of 3 injections of estradiol benzoate (EB; 20 micrograms daily). At 72 h, animals were sacrificed for nuclear progestin receptor (NPR) measurements, while others were tested for reproductive behavior. The remaining animals received 1-mg injections of E2, P, moxestrol (Mox) or oil, and either were sacrificed 2 h later for NPR measurements or were tested 4 h later for reproductive behavior. A subset of the animals receiving 1 mg E2 received concurrent administration of the protein synthesis inhibitor, anisomycin (ANI; 100 mg/kg). Acute administration of 1 mg of E2 or P significantly elevated proceptivity, receptivity and NPRs in the mediobasal hypothalamus-preoptic area (MBH-POA) and pituitary (PIT) in females primed with 100% E2. An equivalent dose of Mox was without effect. ANI blocked the acute activation of feminine reproductive behavior by 1 mg of E2. In the absence of acute steroid administration, animals primed for 72 h with EB showed higher levels of reproductive behavior than animals primed with 100% E2.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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B Parsons; T C Rainbow; L Snyder; B S McEwen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroendocrinology Volume: 39 ISSN: 0028-3835 ISO Abbreviation: Neuroendocrinology Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-09-18 Completed Date: 1984-09-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0035665 Medline TA: Neuroendocrinology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 25-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anisomycin / pharmacology Cell Nucleus / metabolism Estradiol / pharmacology* Estradiol Congeners Ethinyl Estradiol / analogs & derivatives, pharmacology Female Hypothalamus / metabolism* Pituitary Gland / metabolism Progesterone / pharmacology* Promegestone / metabolism Rats Rats, Inbred Strains Receptors, Progesterone / drug effects, metabolism* Sexual Behavior, Animal / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Estradiol Congeners; 0/Receptors, Progesterone; 22862-76-6/Anisomycin; 34184-77-5/Promegestone; 34816-55-2/moxestrol; 50-28-2/Estradiol; 57-63-6/Ethinyl Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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