| Progesterone level and progesterone/estradiol ratio on the day of hCG administration: detrimental cutoff levels and new treatment strategy. | |
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MedLine Citation:
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PMID: 21324450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To identify if there are certain cutoff levels for P and or the P/E(2) ratio on the day of hCG that would be defined as detrimental for occurrence of pregnancy in women with normal ovarian reserve undergoing cleavage-stage embryo transfer (ET). Secondarily, to determine if these same cutoffs might have the same potential negative effect in women undergoing blastocyst ET. DESIGN: Prospective cohort study including two randomized cohorts. SETTING: Private and university fertility centers. PARTICIPANT(S): A total of 240 women undergoing long agonist protocol with at least four grade 1 day 3 embryos. INTERVENTION(S): Women were randomized in a 1:1 ratio to undergo day 3 or day 5 embryo transfer. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (CPR) was the primary outcome. RESULT(S): Using receiver operator characteristics, cutoffs for P and P/E(2) ratio were 1.5 ng/mL and 0.55, respectively. Patients with P ≤ 1.5 ng/mL and P/E(2) ≤ 0.55 undergoing cleavage-stage ET had higher CPR. Using multiple regression, P/E(2) ratio was the only independent predictor for pregnancy. The P and P/E(2) cutoffs were not correlated with CPR in blastocyst transfers. CONCLUSION(S): Progesterone >1.5 ng/mL and P/E(2) >0.55 affect the CPR in women undergoing cleavage-stage, but not blastocyst ET. P/E(2) ratio is the only independent prognosticator for cycle outcome in women undergoing cleavage-stage ET. |
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Authors:
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Eman A Elgindy |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2011-02-16 |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-05-11 Revised Date: 2011-09-07 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1639-44 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Zagazig University School of Medicine, Zagazig, Egypt. eman_elgindy@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / administration & dosage* Drug Administration Schedule Embryo Transfer / methods*, standards Estradiol / blood*, standards Female Fertility Agents, Female / administration & dosage Fertilization in Vitro Humans Infertility, Female / blood*, diagnosis, therapy Pregnancy Pregnancy Rate Progesterone / blood*, standards Prognosis Reference Values Sensitivity and Specificity Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 50-28-2/Estradiol; 57-83-0/Progesterone |
| Comments/Corrections | |
Comment In:
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Fertil Steril. 2011 Aug;96(2):e137; author reply e138
[PMID:
21700281
]
Fertil Steril. 2011 Jun 30;95(8):e61; author reply e62 [PMID: 21536272 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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