Document Detail


Progesterone inhibition of neuronal calcium signaling underlies aspects of progesterone-mediated neuroprotection.
MedLine Citation:
PMID:  22101209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Progesterone is being utilized as a therapeutic means to ameliorate neuron loss and cognitive dysfunction following traumatic brain injury. Although there have been numerous attempts to determine the means by which progesterone exerts neuroprotective effects, studies describing the underlying molecular mechanisms are lacking. What has become clear, however, is the notion that progesterone can thwart several physiological processes that are detrimental to neuron function and survival, including inflammation, edema, demyelination and excitotoxicity. One clue regarding the means by which progesterone has restorative value comes from the notion that these aforementioned biological processes all share the common theme of eliciting pronounced increases in intracellular calcium. Thus, we propose the hypothesis that progesterone regulation of calcium signaling underlies its ability to mitigate these cellular insults, ultimately leading to neuroprotection. Further, we describe recent findings that indicate neuroprotection is achieved via progesterone block of voltage-gated calcium channels, although additional outcomes may arise from blockade of various other ion channels and neurotransmitter receptors. This article is part of a Special Issue entitled 'Neurosteroids'.
Authors:
Jessie I Luoma; Christopher M Stern; Paul G Mermelstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-11-12
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  131     ISSN:  1879-1220     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-07-05     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  30-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Injuries / drug therapy
Calcium Channels / drug effects
Calcium Signaling / drug effects*
Humans
Myelin Sheath / drug effects
Neurons / drug effects*
Neuroprotective Agents / pharmacology*
Progesterone / physiology,  therapeutic use*
Receptors, Glutamate / drug effects
Grant Support
ID/Acronym/Agency:
NS41302/NS/NINDS NIH HHS; R01 NS041302/NS/NINDS NIH HHS; R01 NS041302-09/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channels; 0/Neuroprotective Agents; 0/Receptors, Glutamate; 4G7DS2Q64Y/Progesterone
Comments/Corrections

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