Document Detail

Progesterone induced blocking factor seen in pregnancy lymphocytes soon after implantation.
MedLine Citation:
PMID:  8962661     Owner:  NLM     Status:  MEDLINE    
PROBLEM: The immunomodulatory effect of progesterone (P) in pregnancy manifested via a protein named the P-induced blocking factor (PIBF) was previously reported. The goal of this study was to measure and compare the PIBF expression on lymphocytes between pregnant and non-pregnant women especially in early pregnancy. METHODS: PIBF expression was determined by immunocytochemistry using a PIBF-specific polyclonal antibody. Levels were assessed during the mid-cycle, luteal phase, and first trimester of pregnancy. RESULTS: PIBF expression was found in 24.9% of mid-cycle sera, 49% of luteal phase sera of women who failed to conceive, and 75% of luteal phase sera of women who conceived. CONCLUSIONS: These data indicate that the percentage of PIBF expressing lymphocytes increases as a result of pregnancy and that the stimulus for PIBF induction occurs soon after implantation. These data support the concept that PIBF may play an important role in early implantation possibly by inhibiting the destructive function of natural killer lymphocytes.
J H Check; J Szekeres-Bartho; A O'Shaughnessy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  35     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  277-80     Citation Subset:  IM    
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson University Medical Center, Department of Obstetrics and Gynecology, Camden, USA.
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MeSH Terms
Antigens, Neoplasm / analysis,  biosynthesis*
Embryo Implantation / immunology*
Enzyme-Linked Immunosorbent Assay
Lymphocytes / immunology,  metabolism*
Pregnancy Proteins / biosynthesis*
Progesterone / pharmacology*
Suppressor Factors, Immunologic
Reg. No./Substance:
0/Antigens, Neoplasm; 0/PIBF1 protein, human; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 0/blocking factor; 57-83-0/Progesterone

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