Document Detail

Progesterone-induced augmentation of pituitary gonadotrophin responses to luteinizing hormone-releasing hormone in oestrogen-pre-treated amenorrhoeic women.
MedLine Citation:
PMID:  793269     Owner:  NLM     Status:  MEDLINE    
Modulating effects of oestradiol--17 beta and progesterone on the pituitary responsiveness in luteinizing hormone-releasing hormone (LRH) were investigated in 12 women with functional amenorrhoea. The pituitary reserve capacity for gonadotrophin section was investigated with repeated intravenous LRH tests before and after administration of oestradiol-1 beta followed by either progesterone or saline. Intramuscular injection of 1 mg of oestradiol-17 beta benzoate resulted in a suppression of both the basal gonadotrophin levels in serum and the gonadotrophin responses to LRH 24 h later. Progesterone, 25 mg im, was then administered in eleven experiments. Six h later, when the mean serum progesterone level had increased to levels similar to those seen in the early post-ovulatory phase of the menstrual cycle, there was a marked augmentation of the pituitary capacity to release both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in response to LRH. This was not found in eight experiments where saline was given instead of progesterone after oestrogen pretreatment. These findings suggest that the greatly increased pituitary sensitivity to LRH at midcycle may be caused not only by the oestradiol increase in blood during the late follicular phase but also in part by the small pre-ovulatory rise of progesterone during the mid-cyclic LH peak. Furthermore, they add further support to the hypothesis that progesterone as well as oestradiol is involved in the induction of the LH peak at mid-cycle. Progesterone may be of importance to secure the release of enought LH for ovulation and normal corpus luteum formation to occur.
S J Nillius; L Wide
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  83     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-01-25     Completed Date:  1977-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  684-91     Citation Subset:  IM    
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MeSH Terms
Amenorrhea / physiopathology*
Estradiol / administration & dosage,  pharmacology*
Follicle Stimulating Hormone / secretion
Gonadotropin-Releasing Hormone / administration & dosage,  diagnostic use*
Gonadotropins, Pituitary / blood,  secretion*
Injections, Intramuscular
Injections, Intravenous
Luteinizing Hormone / secretion
Pituitary Gland / secretion*
Pituitary Gland, Anterior / secretion*
Progesterone / administration & dosage,  pharmacology*
Secretory Rate / drug effects
Stimulation, Chemical
Reg. No./Substance:
0/Gonadotropins, Pituitary; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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