| Progesterone enhances the tocolytic effect of ritodrine in isolated pregnant human myometrium. | |
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MedLine Citation:
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PMID: 15695987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of natural progesterone on the relaxant effect of ritodrine on pregnant human oxytocin-induced myometrial contractility. STUDY DESIGN: Isometric tension recordings were performed under physiologic conditions on isolated myometrial strips taken from low-risk term pregnant women undergoing elective cesarean section. Cumulative effects of natural progesterone (10 (-11) to 10 (-5) mol/L) on oxytocin-induced myometrial contractility were evaluated. Contractile activity following ritodrine exposure was also investigated in myometrium pretreated with natural progesterone. RESULTS: Natural progesterone alone exerted a concentration-dependent relaxant effect on myometrial contractions. The concentration-response curve for ritodrine from natural progesterone pretreated myometrium was shifted to the left with a significant reduction ( P < .01) of 50% of the maximal response, contraction amplitude ( P < .05), and frequency ( P < .05). However, there was no significant difference in the mean maximal inhibition achieved ( P = .95). CONCLUSION: Natural progesterone increased the relaxant effect of ritodrine by reducing 50% of the maximal response, amplitude, and frequency of myometrial contraction, most likely through nongenomic actions. These results suggest that natural progesterone may be beneficial for preventing preterm birth in a low-risk population. |
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Authors:
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Boonsri Chanrachakul; Fiona Broughton Pipkin; Averil Y Warren; Sabaratnam Arulkumaran; Raheela N Khan |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 192 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-02-07 Completed Date: 2005-03-10 Revised Date: 2010-12-30 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 458-63 Citation Subset: AIM; IM |
Affiliation:
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Academic Division of Obstetrics and Gynaecology, Derby City General Hospital, University of Nottingham, Derby, DE22 3DT, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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pharmacology* Dose-Response Relationship, Drug Drug Synergism Female Humans Muscle Relaxation / drug effects Myometrium / drug effects* Pregnancy Progesterone / pharmacology* Receptors, Adrenergic, beta-2 / physiology Ritodrine / pharmacology* Tocolytic Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Receptors, Adrenergic, beta-2; 0/Tocolytic Agents; 26652-09-5/Ritodrine; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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