| Progesterone does not prevent preterm births in women with twins. | |
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MedLine Citation:
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PMID: 19668021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare preterm birth rate and neonatal outcome in twin gestations randomized to either 17 alpha-hydroxyprogesterone caproate (17P) or placebo. MATERIALS AND METHODS: Women with twin gestations between 20-30 weeks were randomized to receive weekly injections of either 250 mg 17P injection (Group I), or placebo (Group II). Maternal and neonatal outcome data was recorded. RESULTS: Thirty twin intrauterine pregnancies were randomized; 16 received 17P and 14 received placebo. Demographic data as well as past history and gestational age at randomization were equivalent between groups (P = 0.286-0.847). All patients in both groups were Medicaid recipients. The incidence of preterm labor (P = 0.980), and premature rupture of the membranes (P = 0.525) were the same between groups. Gestational age at delivery was also similar between 17P (33.9 weeks) versus placebo (33.1 weeks, P = 0.190) as was the incidence of preterm birth <35 weeks (44% vs 79%, P = 0.117). Infant weight (P = 0.641), Apgar score at 5 minutes (P = 0.338) as well as neonatal morbidity such as respiratory distress syndrome (P = 0.838), patent ductus arteriosus (P = 0.704), intraventricular hemorrhage (P = 0.851) and necrotizing enterocolitis (P = 0.946) showed no difference. Days spent in the NICU among 17P (18.4) versus placebo (17.3, P = 0.155), neonatal death (P = 0.359) and those infants discharged with neurologic handicap (P = 0.594) were not different between groups. CONCLUSION: Amongst this group of twin gestations weekly 17HP injections did not reduce the incidence of preterm birth or the complications associated with prematurity. |
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Authors:
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Christian M Briery; Edward W Veillon; Chad K Klauser; Rick W Martin; Suneet P Chauhan; Everett F Magann; John C Morrison |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Southern medical journal Volume: 102 ISSN: 1541-8243 ISO Abbreviation: South. Med. J. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-09 Completed Date: 2009-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
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Languages: eng Pagination: 900-4 Citation Subset: AIM; IM |
Affiliation:
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University of TN Chattanooga Unit, Chattanooga, TN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Double-Blind Method Female Fetal Membranes, Premature Rupture / prevention & control Humans Hydroxyprogesterones / administration & dosage* Infant, Newborn Infant, Premature, Diseases Injections, Intramuscular Pregnancy Premature Birth / prevention & control* Progestins / administration & dosage* Treatment Failure Twins* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Hydroxyprogesterones; 0/Progestins; 630-56-8/17-alpha-hydroxy-progesterone caproate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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